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RO7771950 Versus Tucatinib in Combination With Trastuzumab and Capecitabine in People With Locally Advanced or Metastatic Breast Cancer That is Human Epidermal Growth Factor Receptor 2 (HER2)-PositiveRecruiting
NCT07413939Phase 2, Phase 3Updated Aug 5, 2026
Sponsor: Hoffmann-La Roche
HER2-positive Breast Cancer
United States, Argentina, Australia, Austria, Belgium +18 more
An Open-Label, Single-Arm Study to Investigate the Efficacy and Safety of North Star Desiccated Porcine Thyroid Extract Tablets.Recruiting
NCT07747103Phase 3Updated Aug 5, 2026
Sponsor: Neuvosyn Laboratories, LLC
Hypothyroidism
United States
Hormone Replacement Therapy in Adolescents With Premature Ovarian InsufficiencyRecruiting
NCT06851754Phase 3Updated Aug 5, 2026
Sponsor: Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Premature Ovarian Insufficiency
United States
Testing the Addition of Docetaxel (Chemotherapy) to the Usual Treatment (Hormonal Therapy and Apalutamide) for Metastatic Prostate Cancer, ASPIRE TrialRecruiting
NCT06931340Phase 3Updated Aug 5, 2026
Sponsor: Alliance for Clinical Trials in Oncology
Castration-Sensitive Prostate Carcinoma · Metastatic Prostate Adenocarcinoma · Stage IVB Prostate Cancer AJCC v8
United States
A Study to Investigate the Efficacy and Safety of Apraglutide Compared With Placebo in Adult Participants With Short Bowel Syndrome Associated With Intestinal Failure (SBS-IF)Recruiting
NCT07742735Phase 3Updated Aug 4, 2026
Sponsor: VectivBio AG
Short Bowel Syndrome (SBS) · SBS Associated With Intestinal Failure (SBS-IF)
United States, Argentina, Australia, Austria, Belgium +17 more
A Phase III Study to Investigate the Efficacy and Safety of Elecoglipron Compared With Placebo in Adults With Type 2 Diabetes Mellitus on Background InsulinRecruiting
NCT07664553Phase 3Updated Aug 4, 2026
Sponsor: AstraZeneca
Type 2 Diabetes Mellitus
United States, Australia, Bulgaria, Canada, China +8 more
Evaluating the Addition of Adjuvant Chemotherapy to Ovarian Function Suppression Plus Endocrine Therapy in Premenopausal Patients With pN0-1, ER-Positive/HER2-Negative Breast Cancer and an Oncotype Recurrence Score Less Than or Equal to 25Recruiting
NCT05879926Phase 3Updated Aug 4, 2026
Sponsor: NRG Oncology
Breast Cancer
United States, Canada, Colombia, Japan, Mexico +3 more
Phase 2/3 Adaptive Study of VX-147 in Adult and Pediatric Participants With APOL1-Mediated Proteinuric Kidney DiseaseRecruiting
NCT05312879Phase 2, Phase 3Updated Aug 4, 2026
Sponsor: Vertex Pharmaceuticals Incorporated
Proteinuric Kidney Disease
United States, Belgium, Brazil, Canada, Colombia +8 more
CAPRI: A Phase 3 Randomized, Double-Masked Study Comparing the Efficacy of EYP-1901 Against Aflibercept in DMERecruiting
NCT07449923Phase 3Updated Aug 4, 2026
Sponsor: EyePoint Pharmaceuticals, Inc.
Diabetic Macular Edema · DME · Diabetic Macular Edema (DME)
United States, Brazil, Czechia, Germany, Hungary
Perioperative Durvalumab With Neoadjuvant ddMVAC or Gemcitabine/Cisplatin in Patients With Muscle-invasive Bladder Cancer (NIAGARA-2)Recruiting
NCT06960577Phase 3Updated Aug 4, 2026
Sponsor: AstraZeneca
Urinary Bladder Neoplasms · Immune Checkpoint Inhibitors · Methotrexate · Vinblastine
Australia, Brazil, Canada, France, Italy +2 more
A Phase 3 Study of Rezpegaldesleukin (NKTR-358) for Patients ≥ 12 Years of Age With Moderate-to-Severe Atopic DermatitisRecruiting
NCT07690371Phase 3Updated Aug 4, 2026
Sponsor: Nektar Therapeutics
Moderate-to-Severe Atopic Dermatitis
United States
Colon Adjuvant Chemotherapy Based on Evaluation of Residual DiseaseRecruiting
NCT05174169Phase 2, Phase 3Updated Aug 4, 2026
Sponsor: NRG Oncology
Stage III Colon Cancer
United States, Canada, Puerto Rico
AMAZE 2: A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight and Type 2 Diabetes Lose WeightRecruiting
NCT07533175Phase 3Updated Aug 4, 2026
Sponsor: Novo Nordisk A/S
Diabetes Mellitus · Overweight · Obesity
United States, Argentina, Brazil, Croatia, Hungary +5 more
Phase 3 Trial Evaluating the Safety & Efficacy of IMNN-001 Administered in Combination w/ Standard NACT & Adjuvant Chemotherapy in Newly Diagnosed Patients w/ Advanced EOC, Fallopian Tube or Primary Peritoneal CancerRecruiting
NCT06915025Phase 3Updated Aug 4, 2026
Sponsor: Imunon
Epithelial Ovarian Cancer · Ovarian Cancer · Fallopian Tube Cancer · Primary Peritoneal Carcinoma
United States
(HARBOR) Study to Evaluate Efficacy and Safety of BLU-263 Versus Placebo in Patients With Indolent Systemic MastocytosisRecruiting
NCT04910685Phase 2, Phase 3Updated Aug 4, 2026
Sponsor: Blueprint Medicines Corporation
Indolent Systemic Mastocytosis · Smoldering Systemic Mastocytosis
United States, Argentina, Australia, Austria, Belgium +17 more
COMO: A Phase 3 Randomized, Double-Masked Study Comparing the Efficacy of EYP-1901 Against Aflibercept in DMERecruiting
NCT07449936Phase 3Updated Aug 4, 2026
Sponsor: EyePoint Pharmaceuticals, Inc.
Diabetic Macular Edema · DME · Diabetic Macular Edema (DME)
United States, Germany, Israel, Poland, Slovakia
AMAZE 4: A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight and Obstructive Sleep Apnoea Treated With Positive Airway Pressure Lose Weight and Improve Sleep ApnoeaRecruiting
NCT07571109Phase 3Updated Aug 4, 2026
Sponsor: Novo Nordisk A/S
Obesity · Overweight · Obstructive Sleep Apnoea
United States, Australia, China, Germany, India +5 more
Carcinoid Syndrome Efficacy Study Featuring an Oral Daily Paltusotine RegimenRecruiting
NCT07087054Phase 3Updated Aug 4, 2026
Sponsor: Crinetics Pharmaceuticals Inc.
Carcinoid Syndrome · Carcinoid · Carcinoid Tumor · Carcinoid Tumor of Ileum
United States, Argentina, Brazil, Chile, Colombia +8 more
E-Mindfulness Approaches for Living After Breast CancerRecruiting
NCT06748222Phase 3Updated Aug 4, 2026
Sponsor: NRG Oncology
Breast Cancer · Depression
United States, Puerto Rico
A Study to Investigate the Efficacy and Safety of Bemdaneprocel in Adults Who Have Parkinson's DiseaseRecruiting
NCT06944522Phase 3Updated Aug 4, 2026
Sponsor: BlueRock Therapeutics
Parkinsons Disease (PD)
United States, Australia, Canada
A Study of BGM0504 in Early T2DM With ObesityRecruiting
NCT07743983Phase 3Updated Aug 4, 2026
Sponsor: BrightGene Bio-Medical Technology Co., Ltd.
Type 2 Diabetes (T2DM)
China
Phase III Study of Ivonescimab or Bevacizumab Combined With FOLFOX in Patients With Metastatic Colorectal CancerRecruiting
NCT07228832Phase 3Updated Aug 4, 2026
Sponsor: Summit Therapeutics
Metastatic Colorectal Cancer (CRC)
United States, Belgium, Canada, Czechia, France +7 more
A Study of Ifinatamab Deruxtecan in Subjects With Pretreated Advanced or Metastatic Esophageal Squamous Cell Carcinoma (ESCC) (IDeate-Esophageal01)Recruiting
NCT06644781Phase 3Updated Aug 4, 2026
Sponsor: Daiichi Sankyo
Esophageal Squamous Cell Carcinoma
United States, Belgium, China, Denmark, France +12 more
A Phase III Study to Investigate the Efficacy and Safety of Elecoglipron Alone or in Combination With Dapagliflozin Compared With Placebo in Adults With Type 2 Diabetes MellitusRecruiting
NCT07662044Phase 3Updated Aug 4, 2026
Sponsor: AstraZeneca
Type 2 Diabetes Mellitus
United States, Argentina, China, Denmark, Greece +8 more
A Study Comparing TAK-928 With Docetaxel in Adults With Non-Small Cell Lung CancerRecruiting
NCT07217301Phase 3Updated Aug 4, 2026
Sponsor: Takeda
IO-resistant sqNSCLC
United States, China, Japan

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