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Xylitol and the Prevention of Periodontal Disease and Preterm Birth TrialRecruiting
NCT07424846Phase 2, Phase 3Updated Aug 20, 2026
Sponsor: University of Washington
Preterm Birth · Low Birthweight Neonate · Periodontitis · Gingivitis
Malawi
Adding an Immunotherapy Drug, MEDI4736 (Durvalumab), to the Usual Chemotherapy Treatment (Paclitaxel, Cyclophosphamide, and Doxorubicin) for Stage II-III Breast CancerRecruiting
NCT06058377Phase 3Updated Aug 20, 2026
Sponsor: National Cancer Institute (NCI)
Anatomic Stage II Breast Cancer AJCC v8 · Anatomic Stage III Breast Cancer AJCC v8 · HER2-Negative Breast Carcinoma · Hormone Receptor-Positive Breast Carcinoma
United States, Puerto Rico
Study of Datopotamab Deruxtecan Plus Carboplatin or Cisplatin Versus Gemcitabine Plus Carboplatin or Cisplatin in Participants With Locally Advanced or Metastatic Urothelial CarcinomaRecruiting
NCT07129993Phase 2, Phase 3Updated Aug 20, 2026
Sponsor: Daiichi Sankyo
Urothelial Cancer · Bladder Cancer
United States, Austria, China, France, Germany +2 more
Pivotal Study of N-acetyl-L-leucine for CACNA1ARecruiting
NCT07221292Phase 3Updated Aug 20, 2026
Sponsor: IntraBio Inc
CACNA1A · Spinocerebellar Ataxia Type 6 · Episodic Ataxia Type 2 · Familial Hemiplegic Migraine-1
United States, Austria, Germany, Greece, Italy +2 more
A Study to Assess the Efficacy and Safety of Induction and Maintenance Therapy With Afimkibart (RO7790121) in Participants With Moderately to Severely Active Crohn's DiseaseRecruiting
NCT06819878Phase 3Updated Aug 20, 2026
Sponsor: Hoffmann-La Roche
Moderately to Severely Active Crohns Disease
United States, Argentina, Australia, Austria, Belgium +33 more
A Study to Evaluate the Efficacy and Safety of KarXT + KarX-EC for Cognitive Impairment in Alzheimer's DiseaseRecruiting
NCT06976216Phase 3Updated Aug 20, 2026
Sponsor: Bristol-Myers Squibb
Alzheimer's Disease
United States, Argentina, Australia, Brazil, Canada +14 more
A Study to Test if Tenecteplase Helps People to Recover From an Acute Stroke When Given More Than 4.5 Hours After the Person Was Last Seen WellRecruiting
NCT07361302Phase 3Updated Aug 20, 2026
Sponsor: Boehringer Ingelheim
Acute Ischemic Stroke
Argentina, Australia, Bulgaria, China, Greece +11 more
REGN7508 Versus Acetylsalicylic Acid (ASA) for Venous Thromboprophylaxis After Total Knee Arthroplasty in Adult ParticipantsRecruiting
NCT07213778Phase 3Updated Aug 19, 2026
Sponsor: Regeneron Pharmaceuticals
Symptomatic Venous Thromboembolism (VTE)
United States, Greece, Malaysia, Moldova
Phase 3 Study of T-DXd and Rilvegostomig Versus SoC in Advanced HER2-expressing Biliary Tract CancerRecruiting
NCT06467357Phase 3Updated Aug 19, 2026
Sponsor: AstraZeneca
Biliary Tract Cancer
United States, Australia, Austria, Belgium, Brazil +22 more
Study Comparing BEBT-908 Combined With R to SOC for the Treatment of Relapsed/Refractory Diffuse Large B-Cell LymphomaRecruiting
NCT06792253Phase 3Updated Aug 19, 2026
Sponsor: BeBetter Med Inc
Relapsed/Refractory Diffuse Large B-Cell Lymphoma
China
A Study to Evaluate the Drug Levels, Efficacy, and Safety of Deucravacitinib (BMS-986165) in Pediatric Participants With Juvenile Psoriatic ArthritisRecruiting
NCT06869551Phase 3Updated Aug 19, 2026
Sponsor: Bristol-Myers Squibb
Juvenile Psoriatic Arthritis
United States, Brazil, Bulgaria, China, Czechia +6 more
BGB-43395 Plus Letrozole Versus CDK4/6i Plus Letrozole for Patients With Advanced or Metastatic HR+/HER2- Breast Cancer Who Have Not Received Prior Treatment for Advanced or Metastatic DiseaseRecruiting
NCT07492641Phase 3Updated Aug 19, 2026
Sponsor: BeOne Medicines
HR+/HER2- Breast Cancer
United States, Australia, Brazil, China, Japan +5 more
Reducing Adverse Vascular Outcomes With Factor XI Inhibition in Adult Participants With Peripheral Artery DiseaseRecruiting
NCT07318610Phase 3Updated Aug 19, 2026
Sponsor: Regeneron Pharmaceuticals
Peripheral Artery Disease (PAD)
United States
Zilebesiran in Patients With Hypertension Not Adequately Controlled and With Either Established Cardiovascular Disease or High Risk for Cardiovascular DiseaseRecruiting
NCT07181109Phase 3Updated Aug 19, 2026
Sponsor: Alnylam Pharmaceuticals
High Risk Cardiovascular Disease · Hypertension · High Cardiovascular Risk
United States, Argentina, Australia, Austria, Belgium +29 more
EF-41/KEYNOTE D58: Phase 3 Study of Optune Concomitant With Temozolomide Plus Pembrolizumab in Newly Diagnosed GlioblastomaRecruiting
NCT06556563Phase 3Updated Aug 19, 2026
Sponsor: NovoCure GmbH
Glioblastoma
United States, Canada, Czechia, France, Germany +7 more
A Study Of Vagal Nerve Stimulation In Conjunction With NRT For Smoking CessationRecruiting
NCT07487818Phase 2, Phase 3Updated Aug 19, 2026
Sponsor: Mayo Clinic
Smoking Cessation
United States
Dinutuximab With Chemotherapy, Surgery and Stem Cell Transplantation for the Treatment of Children With Newly Diagnosed High Risk NeuroblastomaRecruiting
NCT06172296Phase 3Updated Aug 19, 2026
Sponsor: National Cancer Institute (NCI)
Ganglioneuroblastoma, Nodular · Neuroblastoma
United States, Australia, Canada, New Zealand, Puerto Rico
A Study to Evaluate the Long-term Efficacy and Safety of KarXT + KarX-EC for Agitation in Alzheimer's Disease (ADAGIO-3)Recruiting
NCT06937229Phase 3Updated Aug 19, 2026
Sponsor: Bristol-Myers Squibb
Alzheimer Disease · Agitation
United States, Argentina, Brazil, Bulgaria, Canada +21 more
Clinical Study of Ivonescimab for First-line Treatment of Metastatic NSCLC Patients With High PD-L1Recruiting
NCT06767514Phase 3Updated Aug 19, 2026
Sponsor: Summit Therapeutics
Non-Small Cell Lung Cancer
United States, Belgium, Canada, China, France +12 more
Tenecteplase Before Interhospital Transfer for EVT in Acute Anterior Circulation LVO at 4.5-24 HoursRecruiting
NCT07253181Phase 3Updated Aug 19, 2026
Sponsor: Xuanwu Hospital, Beijing
Acute Ischemic Stroke · Large Vessel Occlusion · Transportation of Patients
China
A Study of the Drugs Selumetinib vs. Carboplatin and Vincristine in Patients With Low-Grade GliomaRecruiting
NCT04166409Phase 3Updated Aug 19, 2026
Sponsor: National Cancer Institute (NCI)
Low Grade Astrocytoma · Low Grade Glioma · Metastatic Low Grade Astrocytoma · Metastatic Low Grade Glioma
United States, Canada, Puerto Rico
A Study With Combinations of Anti-LAG-3 and Anti-PD-1 Antibodies in Adult Participants With Advanced or Metastatic Melanoma (Harmony Head-to-Head)Recruiting
NCT06246916Phase 3Updated Aug 19, 2026
Sponsor: Regeneron Pharmaceuticals
Melanoma
United States, Canada
CLEOPATTRA: A Research Study to Look at the Effects of Treatment With a Medicine Called Coramitug (NNC6019-0001) in People With Heart Failure Due to Transthyretin Amyloid (ATTR) AmyloidosisRecruiting
NCT07207811Phase 3Updated Aug 19, 2026
Sponsor: Novo Nordisk A/S
Transthyretin Amyloid Cardiomyopathy (ATTR CM)
United States, Argentina, Australia, Belgium, Brazil +15 more
Inobrodib, Pomalidomide and Dexamethasone Versus Standard Available Therapy in Relapsed or Refractory Multiple MyelomaRecruiting
NCT07772024Phase 3Updated Aug 19, 2026
Sponsor: CellCentric Ltd.
Multiple Myeloma Refractory · Multiple Myeloma in Relapse
United States
Pivotal Open-label Phase 3 Clinical Study of QTX-2101 in Adult Patients With Acute Promyelocytic LeukemiaRecruiting
NCT07504458Phase 3Updated Aug 19, 2026
Sponsor: Quetzal Therapeutics
Acute Promyelocytic Leukemia (APL) · Acute Promyelocytic Leukaemia · Acute Promyelocytic Leukemia With PML-RARA · Acute Promyelocytic Leukemia With t(15;17)(q24.1;q21.2); PML-RARA
United States, France, Spain

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