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Adding Nivolumab to Usual Treatment for People With Advanced Stomach or Esophageal Cancer, PARAMUNE TrialRecruiting
NCT06203600Phase 2, Phase 3Updated Aug 19, 2026
Sponsor: National Cancer Institute (NCI)
Advanced Esophageal Adenocarcinoma · Advanced Gastric Adenocarcinoma · Advanced Gastroesophageal Junction Adenocarcinoma · Clinical Stage II Esophageal Adenocarcinoma AJCC v8
United States
Orelabrutinib Combined With Teniposide, Rituximab and Methotrexate for Newly Diagnosed PCNSLRecruiting
NCT07185373Phase 2, Phase 3Updated Aug 19, 2026
Sponsor: Huashan Hospital
Primary Central Nervous System Lymphoma
China
Pre-Operative or Post-Operative Stereotactic Radiosurgery in Treating Patients With Operative Metastatic Brain TumorsRecruiting
NCT03750227Phase 3Updated Aug 19, 2026
Sponsor: Mayo Clinic
Malignant Solid Neoplasm · Metastatic Malignant Neoplasm in the Brain
United States
A Study Evaluating the Efficacy and Safety of Xywav Expanded Dosing vs Placebo in Participants With Narcolepsy or IHRecruiting
NCT07625280Phase 3Updated Aug 19, 2026
Sponsor: Jazz Pharmaceuticals
Narcolepsy · Idiopathic Hypersomnia
United States
A Study of Camizestrant in ER+/HER2- Early Breast Cancer After at Least 2 Years of Standard Adjuvant Endocrine TherapyRecruiting
NCT05774951Phase 3Updated Aug 19, 2026
Sponsor: AstraZeneca
Breast Cancer, Early Breast Cancer
United States, Argentina, Australia, Austria, Belgium +34 more
A Study to Investigate Velzatinib Compared With Imatinib in Adult Participants With Previously Untreated Metastatic and/or Unresectable Gastrointestinal Stromal Tumors (StrateGIST Frontline)Recruiting
NCT07585266Phase 3Updated Aug 19, 2026
Sponsor: GlaxoSmithKline
Gastrointestinal Stromal Neoplasms
United States, Argentina, Canada, China, Japan +2 more
Measuring if Immunotherapy Plus Chemotherapy is Better Than Chemotherapy Alone for Patients With Aggressive Poorly Differentiated SarcomasRecruiting
NCT06422806Phase 3Updated Aug 19, 2026
Sponsor: National Cancer Institute (NCI)
Metastatic Dedifferentiated Liposarcoma · Metastatic Undifferentiated Pleomorphic Sarcoma · Stage III Soft Tissue Sarcoma of the Trunk and Extremities AJCC v8 · Stage IV Soft Tissue Sarcoma of the Trunk and Extremities AJCC v8
United States, Canada, Puerto Rico
Trial Investigating the Efficacy and Safety of Weekly Lonapegsomatropin Compared to Daily Somatropin in Children and Adolescents With Short Stature or Growth Failure Due to Growth Hormone Sufficient DisordersRecruiting
NCT07221851Phase 3Updated Aug 19, 2026
Sponsor: Ascendis Pharma A/S
Turner Syndrome · Short Stature Homeobox Gene Mutation · Idiopathic Short Stature · Small for Gestational Age at Delivery
United States, France, Germany, Italy, Romania +2 more
A Study to Evaluate the Efficacy and Safety of Once Daily Treprostinil Palmitil Inhalation Powder (TPIP) in Participants With Pulmonary Arterial Hypertension (PAH)Recruiting
NCT07481981Phase 3Updated Aug 19, 2026
Sponsor: Insmed Incorporated
Pulmonary Arterial Hypertension
United States, Japan
A Study to Evaluate Efficacy of Remibrutinib Compared to Dupilumab at Early Timepoints in Adults With Chronic Spontaneous Urticaria Inadequately Controlled by Second Generation H1-antihistaminesRecruiting
NCT06868212Phase 3Updated Aug 19, 2026
Sponsor: Novartis Pharmaceuticals
Chronic Spontaneous Urticaria (CSU)
United States
A Study to Learn More About How Well Sevabertinib Works and How Safe it is Compared With Standard Treatment, in Participants Who Have Advanced Non-small Cell Lung Cancer (NSCLC) With Mutations of the Human Epidermal Growth Factor Receptor 2 (HER2)Recruiting
NCT06452277Phase 3Updated Aug 19, 2026
Sponsor: Bayer
Advanced Non-small Cell Lung Cancer, HER2 Mutation
United States, Argentina, Australia, Austria, Belgium +31 more
Blood-brain Barrier (BBB) Opening Using Exablate Focused Ultrasound With Standard of Care Treatment of NSCLC Brain MetsRecruiting
NCT05317858Phase 3Updated Aug 19, 2026
Sponsor: InSightec
Brain Tumor · Non Small Cell Lung Cancer
United States, Canada, South Korea
Evaluation of a Disability-Focused Sexual and Reproductive Health Curriculum for Health Students in TanzaniaRecruiting
NCT07772778Phase 3Updated Aug 19, 2026
Sponsor: University of Minnesota
Sexual and Reproductive Health · Disability · Health Knowledge, Attitudes, Practice · Health Education
Tanzania
LEVEL-2: LEVosimendan to Improve Exercise Limitation in Patients With PH-HFpEF-2Recruiting
NCT07288398Phase 3Updated Aug 19, 2026
Sponsor: Tenax Therapeutics, Inc.
Pulmonary Hypertension Associated With HFpEF
United States, Argentina, Austria, Brazil, Bulgaria +10 more
Roll-over Study for Participants Who Have Completed a Previous Clinical Study With Benralizumab (Fasenra) and Benefit From Continued TreatmentRecruiting
NCT07444567Phase 3Updated Aug 19, 2026
Sponsor: AstraZeneca
Asthma · Eosinophilic Granulomatosis With Polyangiitis (EGPA) · Hypereosinophilic Syndrome (HES)
United States, Argentina, Austria, Belgium, Canada +9 more
A Study Evaluating Efruxifermin in Subjects With Compensated Cirrhosis Due to NASH/MASHRecruiting
NCT06528314Phase 3Updated Aug 19, 2026
Sponsor: Akero Therapeutics, Inc
NASH - Nonalcoholic Steatohepatitis · MASH - Metabolic Dysfunction-Associated Steatohepatitis
United States, Argentina, Australia, Brazil, Canada +15 more
Phase 3 Study to Assess Efficacy, Safety & Tolerability of OCU410 For Geographic Atrophy Secondary to Dry AMDRecruiting
NCT07770828Phase 3Updated Aug 19, 2026
Sponsor: Ocugen
Dry Age-related Macular Degeneration
United States
Testing the Addition of Herceptin Hylecta or Phesgo to the Usual Chemotherapy for HER2 Positive Endometrial Serous Carcinoma or CarcinosarcomaRecruiting
NCT05256225Phase 3Updated Aug 19, 2026
Sponsor: National Cancer Institute (NCI)
Endometrial Carcinoma · Endometrial Clear Cell Adenocarcinoma · Endometrial Dedifferentiated Carcinoma · Endometrial Endometrioid Adenocarcinoma
United States, Puerto Rico, South Korea
A Study to Investigate the Efficacy and Safety of Sonrotoclax Plus Zanubrutinib Compared With Placebo Plus Zanubrutinib in Adults With Relapsed/Refractory Mantle Cell Lymphoma (CELESTIAL-RRMCL)Recruiting
NCT06742996Phase 3Updated Aug 19, 2026
Sponsor: BeOne Medicines
Mantle Cell Lymphoma · B Cell Lymphoma
United States, Argentina, Australia, Austria, Brazil +12 more
Testing the Addition of Paclitaxel Administered Into the Abdominal Cavity Combined With Chemotherapy for Patients With Gastric Cancer Spread to the Abdominal CavityRecruiting
NCT07001748Phase 2, Phase 3Updated Aug 19, 2026
Sponsor: ECOG-ACRIN Cancer Research Group
Gastric Adenocarcinoma · Gastroesophageal Junction Adenocarcinoma · Peritoneal Carcinomatosis
United States
A Study to Determine if BHV-8000 is Effective, Safe and Tolerable as a Treatment for Adults Living With Early Parkinson's DiseaseRecruiting
NCT06976268Phase 2, Phase 3Updated Aug 19, 2026
Sponsor: Biohaven Therapeutics Ltd.
Parkinson Disease
United States
Evaluation of the Safety and Efficacy of Abenacianine (VGT-309) to Identify Cancer in Subjects Undergoing Surgery for Cancer in the LungRecruiting
NCT07499674Phase 3Updated Aug 19, 2026
Sponsor: Vergent Bioscience, Inc.
Lung Cancer · Lung Metastases
United States, Australia
A Study to Learn More About the Effects and Safety of Felzartamab Infusions in Adults With Primary Membranous Nephropathy (PMN)Recruiting
NCT06962800Phase 3Updated Aug 19, 2026
Sponsor: Biogen
Primary Membranous Nephropathy
United States, Argentina, Australia, Brazil, Canada +6 more
Efficacy and Safety of 4F-PCC (4-Factor Prothrombin Complex Concentrate) in Adult Patients Undergoing Complex Cardiovascular Surgery With Cardiopulmonary Bypass (CPB)Recruiting
NCT07094087Phase 3Updated Aug 18, 2026
Sponsor: CSL Behring
Complex Cardiovascular Surgery With Cardiopulmonary Bypass
United States, Canada, Japan, Mexico
Research Study on How Well Oral Semaglutide Works for Weight Loss in Adults With Excess Body WeightRecruiting
NCT07770841Phase 3Updated Aug 18, 2026
Sponsor: Novo Nordisk A/S
Overweight · Obesity
United States, Belgium, Bulgaria, Denmark, France +5 more

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