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Osimertinib With or Without Bevacizumab as Initial Treatment for Patients With EGFR-Mutant Lung CancerRecruiting
NCT04181060Phase 3Updated Aug 19, 2026
Sponsor: National Cancer Institute (NCI)
Advanced Lung Non-Squamous Non-Small Cell Carcinoma · Metastatic Lung Non-Squamous Non-Small Cell Carcinoma · Recurrent Lung Non-Squamous Non-Small Cell Carcinoma · Stage IIIB Lung Cancer AJCC v8
United States
COMparison Between Anakinra and Tocilizumab in NORSE - "COMBAT-NORSE"Not Yet Recruiting
NCT07281027Phase 3Updated Aug 19, 2026
Sponsor: Yale University
New Onset Refractory Status Epilepticus · New-Onset Refractory Status Epilepticus · Febrile Infection-Related Epilepsy Syndrome (FIRES)
United States, Canada, France, Italy, South Korea +2 more
A Study of the Drug Selinexor With Radiation Therapy in Patients With Newly-Diagnosed Diffuse Intrinsic Pontine (DIPG) Glioma and High-Grade Glioma (HGG)Recruiting
NCT05099003Phase 1, Phase 2Updated Aug 19, 2026
Sponsor: National Cancer Institute (NCI)
Malignant Glioma
United States, Australia, Canada, New Zealand
A Study to Test the Addition of the Drug Cabozantinib to Chemotherapy in Patients With Newly Diagnosed OsteosarcomaSuspended
NCT05691478Phase 2, Phase 3Updated Aug 19, 2026
Sponsor: National Cancer Institute (NCI)
High Grade Osteosarcoma · Localized Osteosarcoma · Metastatic Osteosarcoma · Secondary Osteosarcoma
United States, Australia, Canada, New Zealand
A Study With Tovorafenib (DAY101) as a Treatment Option for Progressive, Relapsed, or Refractory Langerhans Cell HistiocytosisRecruiting
NCT05828069Phase 2Updated Aug 19, 2026
Sponsor: National Cancer Institute (NCI)
Recurrent Langerhans Cell Histiocytosis · Refractory Langerhans Cell Histiocytosis
United States, Australia, Canada
Radiation Therapy With or Without Cisplatin in Treating Patients With Stage III-IVA Squamous Cell Carcinoma of the Head and Neck Who Have Undergone SurgeryRecruiting
NCT02734537Phase 2Updated Aug 19, 2026
Sponsor: ECOG-ACRIN Cancer Research Group
Head and Neck Squamous Cell Carcinoma · Hypopharyngeal Squamous Cell Carcinoma · Laryngeal Squamous Cell Carcinoma · Laryngeal Squamous Cell Carcinoma, Spindle Cell Variant
United States
Testing the Addition of an Antibody to Standard Chemoradiation Followed by the Antibody for One Year to Standard Chemoradiation Followed by One Year of the Antibody in Patients With Unresectable Stage III Non-Small Cell Lung CancerActive Not Recruiting
NCT04092283Phase 3Updated Aug 19, 2026
Sponsor: National Cancer Institute (NCI)
Recurrent Lung Non-Small Cell Carcinoma · Stage III Lung Cancer AJCC v8 · Stage IIIA Lung Cancer AJCC v8 · Stage IIIB Lung Cancer AJCC v8
United States, Guam
Drug-Eluting Registry: Real-World Treatment of Lesions in the Peripheral VasculatureRecruiting
NCT04674969N/AUpdated Aug 19, 2026
Sponsor: Boston Scientific Corporation
Peripheral Vascular Diseases
United States, Australia, Austria, Canada, China +7 more
Lenalidomide, and Dexamethasone With or Without Daratumumab in Treating Patients With High-Risk Smoldering MyelomaRecruiting
NCT03937635Phase 3Updated Aug 19, 2026
Sponsor: ECOG-ACRIN Cancer Research Group
Smoldering Plasma Cell Myeloma
United States, Puerto Rico
Testing the Use of Combination Therapy in Adult Patients With Newly Diagnosed Multiple Myeloma, the EQUATE TrialRecruiting
NCT04566328Phase 3Updated Aug 19, 2026
Sponsor: ECOG-ACRIN Cancer Research Group
Plasma Cell Myeloma · RISS Stage I Plasma Cell Myeloma · RISS Stage II Plasma Cell Myeloma
United States, Puerto Rico
Treating Prostate Cancer That Has Come Back After Surgery With Apalutamide and Targeted Radiation Based on PET ImagingRecruiting
NCT04423211Phase 3Updated Aug 19, 2026
Sponsor: ECOG-ACRIN Cancer Research Group
Biochemically Recurrent Prostate Carcinoma · Metastatic Prostate Carcinoma · Prostate Adenocarcinoma · Stage IVB Prostate Cancer AJCC v8
United States
The Rhythm Evaluation for AntiCoagulaTion With Continuous Monitoring of Atrial FibrillationRecruiting
NCT05836987Phase 3Updated Aug 19, 2026
Sponsor: Johns Hopkins University
Atrial Fibrillation
United States
Virtual Tai Chi for Chronic Low Back Pain (Spine 2027)Not Yet Recruiting
NCT07772154NAUpdated Aug 19, 2026
Sponsor: New York Medical College
Low Back Pain · Chronic Low-back Pain (cLBP)
United States
Testing the Effectiveness of Two Immunotherapy Drugs (Nivolumab and Ipilimumab) With One Anti-cancer Targeted Drug (Cabozantinib) for Rare Genitourinary TumorsRecruiting
NCT03866382Phase 2Updated Aug 19, 2026
Sponsor: National Cancer Institute (NCI)
Bladder Adenocarcinoma · Bladder Clear Cell Adenocarcinoma · Bladder Mixed Adenocarcinoma · Bladder Neuroendocrine Carcinoma
United States, Puerto Rico
ATEMPT 2.0: Adjuvant T-DM1 vs THRecruiting
NCT04893109Phase 2Updated Aug 19, 2026
Sponsor: Dana-Farber Cancer Institute
Breast Cancer · HER2-positive Breast Cancer
United States
Venetoclax and HMA Treatment of Older and Unfit Adults With FLT3 Mutated Acute Myeloid Leukemia (AML) (A MyeloMATCH Treatment Trial)Recruiting
NCT06317649Phase 2Updated Aug 19, 2026
Sponsor: National Cancer Institute (NCI)
Acute Myeloid Leukemia
United States, Puerto Rico
PODOMOUNT-Basket, a Study to Test Whether BI 764198 Helps Adults and Adolescents With Different Types of Kidney DiseaseRecruiting
NCT07355296Phase 2Updated Aug 19, 2026
Sponsor: Boehringer Ingelheim
Proteinuric Kidney Diseases
United States, Argentina, Australia, Belgium, Brazil +28 more
Testing the Addition of Herceptin Hylecta or Phesgo to the Usual Chemotherapy for HER2 Positive Endometrial Serous Carcinoma or CarcinosarcomaRecruiting
NCT05256225Phase 3Updated Aug 19, 2026
Sponsor: National Cancer Institute (NCI)
Endometrial Carcinoma · Endometrial Clear Cell Adenocarcinoma · Endometrial Dedifferentiated Carcinoma · Endometrial Endometrioid Adenocarcinoma
United States, Puerto Rico, South Korea
Veteran Peer Navigators to Promote Shared Decision Making for PSA ScreeningNot Yet Recruiting
NCT06549036NAUpdated Aug 19, 2026
Sponsor: VA Office of Research and Development
Prostate Cancer
United States
Targeted Therapy Directed by Genetic Testing in Treating Patients With Locally Advanced or Advanced Solid Tumors, The ComboMATCH Screening TrialRecruiting
NCT05564377Phase 2Updated Aug 19, 2026
Sponsor: National Cancer Institute (NCI)
Advanced Malignant Solid Neoplasm · Anatomic Stage III Breast Cancer AJCC v8 · Anatomic Stage IV Breast Cancer AJCC v8 · Locally Advanced Malignant Solid Neoplasm
United States, Puerto Rico
Testing the Use of Neratinib or the Combination of Neratinib and Palbociclib Targeted Treatment for HER2+ Solid Tumors (A ComboMATCH Treatment Trial)Recruiting
NCT06126276Phase 2Updated Aug 18, 2026
Sponsor: National Cancer Institute (NCI)
Malignant Female Reproductive System Neoplasm · Malignant Solid Neoplasm · Recurrent Malignant Female Reproductive System Neoplasm · Recurrent Malignant Solid Neoplasm
United States, Puerto Rico
A Maintenance Study to Investigate the Efficacy and Safety of Duvakitug in Participants With Moderately to Severely Active Ulcerative ColitisRecruiting
NCT07185009Phase 3Updated Aug 18, 2026
Sponsor: Sanofi
Ulcerative Colitis
United States, Canada, Georgia, Japan, Lithuania +3 more
Combining Immunotherapy and Radiation Therapy to Help Patients Avoid Bladder Removal After Treatment Shrinks Muscle Invasive Bladder Cancer, BRIGHT TrialRecruiting
NCT07061964Phase 2Updated Aug 18, 2026
Sponsor: National Cancer Institute (NCI)
Muscle Invasive Bladder Urothelial Carcinoma · Stage II Bladder Cancer AJCC v8 · Stage IIIA Bladder Cancer AJCC v8
United States
Trametinib and Everolimus for Treatment of Pediatric and Young Adult Patients With Recurrent Gliomas (PNOC021)Recruiting
NCT04485559Phase 1Updated Aug 18, 2026
Sponsor: University of California, San Francisco
Recurrent World Health Organization (WHO) Grade II Glioma · Low-grade Glioma · High-Grade Glioma (HGG)
United States
Long-Term Extension Study for Participants Previously Enrolled in an Exelixis-Sponsored StudyEnrolling By Invitation
NCT07620574Phase 3Updated Aug 18, 2026
Sponsor: Exelixis
Cancer · Renal Cell Carcinoma (RCC) · Pancreatic Neuroendocrine Tumors (pNET) · Extra-Pancreatic NET (epNET)
United States

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