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A Study of Precemtabart Tocentecan With or Without Bevacizumab Compared to Trifluridine/Tipiracil Plus Bevacizumab in Participants With Previously Treated Metastatic Colorectal Cancer (PROCEADE-CRC-03)Recruiting
NCT07549412Phase 3Updated Aug 14, 2026
Sponsor: EMD Serono Research & Development Institute, Inc.
Metastatic Colorectal Cancer
United States, Australia, Canada, China, Japan +2 more
Non-inferiority Study of Frexalimab Subcutaneous Administration Compared to Intravenous Administration in Adult Participants With Multiple SclerosisRecruiting
NCT07325292Phase 3Updated Aug 14, 2026
Sponsor: Sanofi
Multiple Sclerosis
United States, Belgium, China, Italy, Japan
A Clinical Study of Patritumab Deruxtecan to Treat Breast Cancer (MK-1022-016)Recruiting
NCT07060807Phase 3Updated Aug 14, 2026
Sponsor: Merck Sharp & Dohme LLC
Breast Neoplasms
United States, Argentina, Australia, Brazil, Canada +21 more
A Study to Compare the Efficacy and Safety of BMS-986489 (BMS-986012+ Nivolumab Fixed Dose Combination) in Combination With Carboplatin Plus Etoposide to That of Atezolizumab With Carboplatin Plus Etoposide as First-Line Therapy in Participants With Extensive-Stage Small Cell Lung Cancer (TIGOS).Recruiting
NCT06646276Phase 3Updated Aug 14, 2026
Sponsor: Bristol-Myers Squibb
Extensive-Stage Small Cell Lung Cancer
United States, Argentina, Australia, Austria, Belgium +21 more
A Study to Learn About a Clostridioides Difficile Vaccine in People 65 Years of Age and OlderRecruiting
NCT07282665Phase 3Updated Aug 14, 2026
Sponsor: Pfizer
Clostridoides Difficile Associated Disease
United States, Argentina, Japan, United Kingdom
TRITON-CM: A Study to Evaluate Nucresiran in Patients With Transthyretin Amyloidosis With CardiomyopathyRecruiting
NCT07052903Phase 3Updated Aug 14, 2026
Sponsor: Alnylam Pharmaceuticals
Transthyretin Amyloidosis With Cardiomyopathy
United States, Argentina, Australia, Austria, Belgium +30 more
A Clinical Study Evaluating the Diagnostic Performance and Safety of PET for the Deposition of Aβ Plaques in the Brain of Participants With Normal Cognitive Function, MCI and AD Using [18F]Fluorbetazine InjectionRecruiting
NCT07764679Phase 3Updated Aug 14, 2026
Sponsor: HTA Co., Ltd.
Mild Cognitive Impairment (MCI) · Alzheimer's Disease (AD)
China
A Clinical Trial of Sacituzumab Tirumotecan (Sac-TMT, MK-2870) to Treat Urothelial Cancer (MK-2870-031)Recruiting
NCT07419295Phase 3Updated Aug 14, 2026
Sponsor: Merck Sharp & Dohme LLC
Bladder Cancer
United States, Argentina, Australia, Belgium, Brazil +11 more
Safety and Efficacy of EXV-802 and EXV-801 in the Treatment of Agitation in Alzheimer's Disease DementiaRecruiting
NCT07284472Phase 2, Phase 3Updated Aug 14, 2026
Sponsor: Exciva GmbH
Agitation Associated With Alzheimer's Disease Dementia
United States, Canada, Czechia, Germany, Italy +4 more
TRITON-PN: A Study to Evaluate the Efficacy and Safety of Nucresiran in Patients With Hereditary Transthyretin Amyloidosis With PolyneuropathyRecruiting
NCT07223203Phase 3Updated Aug 14, 2026
Sponsor: Alnylam Pharmaceuticals
Hereditary Transthyretin-Mediated Amyloidosis With Polyneuropathy · hATTR-PN
United States, Australia, Brazil, Canada, Cyprus +12 more
Study to Evaluate Weight Gain as Assessed by Change in BMI Z-score in Pediatric Subjects With Schizophrenia or Bipolar I DisorderRecruiting
NCT05303064Phase 3Updated Aug 14, 2026
Sponsor: Alkermes, Inc.
Schizophrenia · Bipolar I Disorder
United States, Argentina, Brazil, Colombia, Mexico
A Study to Evaluate the Efficacy and Safety of AXS-05 for Smoking Cessation in AdultsRecruiting
NCT07766655Phase 3Updated Aug 14, 2026
Sponsor: Axsome Therapeutics, Inc.
Smoking Cessation
United States
A Clinical Study of Sacituzumab Tirumotecan (Sac-TMT, MK-2870) in People With Breast Cancer (MK-2870-032)Recruiting
NCT06966700Phase 3Updated Aug 14, 2026
Sponsor: Merck Sharp & Dohme LLC
Breast Neoplasms · Triple Negative Breast Neoplasms · HR Low-Positive/HER2-Negative Breast Neoplasms
United States, Argentina, Australia, Belgium, Brazil +34 more
A Phase 3 Study of Revaccination in Subsequent Pregnancies With Bivalent RSV Vaccine and Duration of Protection of a Single DoseRecruiting
NCT06866405Phase 3Updated Aug 14, 2026
Sponsor: Pfizer
RSV Infection
United States, Argentina, South Africa, The Gambia
Clarifying the Optimal Application of SLT Therapy TrialRecruiting
NCT04967989Phase 3Updated Aug 14, 2026
Sponsor: University of Pittsburgh
Glaucoma and Ocular Hypertension
United States, Canada
A Study to Learn How PF-06821497 (Mevrometostat) Works in Men With Metastatic Castration-resistant Prostate Cancer.Recruiting
NCT06629779Phase 3Updated Aug 14, 2026
Sponsor: Pfizer
Metastatic Castration-Resistant Prostate Cancer
United States, Argentina, Brazil, Bulgaria, Canada +22 more
A Study to Test the Efficacy and Safety of Staccato Alprazolam in Study Participants 12 Years of Age and Older With Stereotypical Prolonged SeizuresRecruiting
NCT05077904Phase 3Updated Aug 14, 2026
Sponsor: UCB Biopharma SRL
Stereotypical Prolonged Seizures
United States, Australia, Bulgaria, China, Czechia +8 more
Study of Lenacapavir, Teropavimab, and Zinlirvimab Versus Cabotegravir and Rilpivirine in Virologically Suppressed Adults With HIV-1 on Oral Daily Antiretroviral TherapyRecruiting
NCT07682961Phase 3Updated Aug 14, 2026
Sponsor: Gilead Sciences
HIV Infections
United States, Australia, Japan
Study of Petosemtamab Plus Chemotherapy Versus Cetuximab Plus Chemotherapy in RAS and BRAF Wild-type, Unresectable or Metastatic, Left-sided Colorectal Cancer (LiGeR-CRC1)Recruiting
NCT07702032Phase 3Updated Aug 14, 2026
Sponsor: Genmab
Left-sided Colorectal Cancer
United States, Puerto Rico
Psilocybin Intervention for Veterans Overcoming Treatment-Resistant DepressionRecruiting
NCT07226232Phase 3Updated Aug 14, 2026
Sponsor: VA Office of Research and Development
Major Depression
United States
Surabgene Lomparvovec Administered in the Suprachoroidal Space in Adult Participants With Diabetic Retinopathy Without Center-Involved Diabetic Macular EdemaRecruiting
NCT07592273Phase 2, Phase 3Updated Aug 14, 2026
Sponsor: AbbVie
Diabetic Retinopathy
United States, Puerto Rico
Long-term Safety Study of Rimegepant in Pediatric Subjects for the Acute Treatment of MigraineRecruiting
NCT04743141Phase 3Updated Aug 14, 2026
Sponsor: Pfizer
Acute Treatment of Migraine
United States, Poland, Spain
A Study to Learn About the Study Medicine Ibuzatrelvir in Adults With COVID-19 Who Are Severely ImmunocompromisedRecruiting
NCT07013474Phase 3Updated Aug 14, 2026
Sponsor: Pfizer
COVID-19 Infection
United States, Argentina, Belgium, Brazil, Denmark +13 more
MagnetisMM-32: A Study to Learn About the Study Medicine Called Elranatamab in People With Multiple Myeloma (MM) That Has Come Back After Taking Other Treatments (Including Prior Treatment With an Anti-CD38 Antibody and Lenalidomide)Recruiting
NCT06152575Phase 3Updated Aug 14, 2026
Sponsor: Pfizer
Multiple Myeloma
United States, Argentina, Australia, Belgium, Brazil +22 more
A Continued Access Study for Participants Transitioning From ViiV Healthcare-sponsored or ViiV Healthcare-collaborative Parent Studies for HIV TreatmentRecruiting
NCT07393659Phase 3Updated Aug 14, 2026
Sponsor: ViiV Healthcare
HIV Infections
South Africa

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