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A Study of Adagrasib Plus Pembrolizumab Plus Chemotherapy vs. Placebo Plus Pembrolizumab Plus Chemotherapy in Participants With Previously Untreated Non-squamous Non-small Cell Lung Cancer With KRAS G12C Mutation (KRYSTAL-4)Recruiting
NCT06875310Phase 3Updated Aug 14, 2026
Sponsor: Mirati Therapeutics Inc.
Carcinoma, Non-Small-Cell Lung
United States, Argentina, Australia, Austria, Belgium +30 more
A Study of Once-daily Oral ASC30 to Evaluate the Efficacy and Safety in Adult Participants With Obesity or Overweight With Weight-Related ComorbiditiesRecruiting
NCT07743463Phase 3Updated Aug 14, 2026
Sponsor: Ascletis Pharma (China) Co., Limited
Obesity · Overweight · Chronic Weight Management
United States, Canada, Czechia, Germany, Greece +2 more
A Study of Once-daily Oral ASC30 to Evaluate the Efficacy and Safety in Adult Participants With Obesity or Overweight With Type 2 DiabetesRecruiting
NCT07743450Phase 3Updated Aug 14, 2026
Sponsor: Ascletis Pharma (China) Co., Limited
Obesity · Overweight · Chronic Weight Management · Type 2 Diabetes Mellitus
United States, Czechia, Germany, Greece, Poland +1 more
A Study of Sacituzumab Tirumotecan (MK-2870) as a Single Agent and in Combination With Pembrolizumab (MK-3475) Versus Treatment of Physician's Choice in Participants With HR+/HER2- Unresectable Locally Advanced or Metastatic Breast Cancer (MK-2870-010)Recruiting
NCT06312176Phase 3Updated Aug 14, 2026
Sponsor: Merck Sharp & Dohme LLC
Breast Neoplasms
United States, Argentina, Australia, Belgium, Brazil +35 more
A Follow-up Study of Mezagitamab in Adults With Chronic Primary Immune ThrombocytopeniaRecruiting
NCT06948318Phase 3Updated Aug 14, 2026
Sponsor: Takeda
Immune Thrombocytopenic Purpura (ITP)
United States, Australia, Bulgaria, China, Croatia +10 more
A Study to Evaluate the Pharmacokinetics, Safety and Efficacy of Afimkibart (RO7790121) in Children With Moderately to Severely Active Ulcerative ColitisRecruiting
NCT07158242Phase 3Updated Aug 14, 2026
Sponsor: Hoffmann-La Roche
Moderately to Severely Active Ulcerative Colitis
United States, Australia, Brazil, Canada, China +4 more
Study of an Injectable Regimen of GS-3242 With Lenacapavir Compared to Biktarvy in People New to HIV-1 TreatmentRecruiting
NCT07708727Phase 2, Phase 3Updated Aug 14, 2026
Sponsor: Gilead Sciences
HIV-1-infection
United States, Puerto Rico
A Study of Suvorexant (MK-4305) for the Treatment of Insomnia Disorder in Participants With Opioid Use Disorder (MK-4305-098)Recruiting
NCT06655883Phase 3Updated Aug 14, 2026
Sponsor: Merck Sharp & Dohme LLC
Insomnia
United States
A Gaucher Disease Gene Therapy Trial With FLT201Recruiting
NCT07223944Phase 3Updated Aug 14, 2026
Sponsor: Spur Therapeutics
Gaucher Disease Type 1
United States, Argentina, Australia, Brazil, Canada +5 more
A Study of Enpatoran in Participants With Cutaneous Manifestations of Lupus With or Without Systemic DiseaseRecruiting
NCT07332481Phase 3Updated Aug 14, 2026
Sponsor: EMD Serono Research & Development Institute, Inc.
Systemic Lupus Erythematosus (SLE) · Cutaneous Lupus Erythematosus (CLE)
United States, Japan, Switzerland
A Study to Assess Intravenous (IV) Telisotuzumab Adizutecan in Combination With Fluorouracil, Folinic Acid, and Oxaliplatin (FOLFOX) Compared to Standard of Care in Adult Participants With First-Line Metastatic Pancreatic Ductal AdenocarcinomaRecruiting
NCT07490301Phase 2, Phase 3Updated Aug 14, 2026
Sponsor: AbbVie
Metastatic Pancreatic Ductal Adenocarcinoma · PDAC
United States, Australia, Israel, Italy, Japan +3 more
A Study to Assess Adverse Events and Effectiveness of Gel Stent (XEN63) Implantation Using Ab Interno and Ab Externo Approaches in Adult Participants With GlaucomaRecruiting
NCT06822738Phase 3Updated Aug 14, 2026
Sponsor: AbbVie
Primary Open Angle Glaucoma
United States
Privosegtor Investigation in Optic Neuropathies Efficacy Evaluation ResearchRecruiting
NCT07623668Phase 3Updated Aug 14, 2026
Sponsor: Oculis
Optic Neuritis
United States
A Global Phase III Study of Rilvegostomig or Pembrolizumab Plus Chemotherapy for First-Line Treatment of Locally Advanced or Metastatic Non-Squamous NSCLCRecruiting
NCT06627647Phase 3Updated Aug 14, 2026
Sponsor: AstraZeneca
Non-squamous Non-small Cell Lung Cancer
United States, Argentina, Australia, Belgium, Brazil +20 more
Maridebart Cafraglutide Versus Placebo in Adult Participants With Obstructive Sleep Apnea Not on Positive Airway Pressure (PAP) TherapyRecruiting
NCT07226765Phase 3Updated Aug 14, 2026
Sponsor: Amgen
Obstructive Sleep Apnea
United States, Australia, Brazil, Canada, Czechia +6 more
A Clinical Study of Molnupiravir to Prevent Severe Illness From Coronavirus Disease 2019 (COVID-19) in People Who Are High Risk (MK-4482-023)Recruiting
NCT06667700Phase 3Updated Aug 14, 2026
Sponsor: Merck Sharp & Dohme LLC
Coronavirus Disease (COVID-19)
United States, Argentina, Brazil, Bulgaria, Colombia +19 more
A Clinical Study to Evaluate the Effects of Enicepatide (RO7795068) in Participants With Obesity or Overweight and Type 2 DiabetesRecruiting
NCT07351058Phase 3Updated Aug 14, 2026
Sponsor: Hoffmann-La Roche
Obesity or Overweight · Type 2 Diabetes Mellitus
United States, Argentina, Australia, Brazil, Canada +15 more
A Clinical Study of B007 in the Treatment of Generalized Myasthenia Gravis.Recruiting
NCT06447597Phase 2, Phase 3Updated Aug 14, 2026
Sponsor: Shanghai Jiaolian Drug Research and Development Co., Ltd
Generalized Myasthenia Gravis
China
Megestrol Acetate for Fatigue Management in T-DXd Treated Breast CancerRecruiting
NCT07543536Phase 3Updated Aug 14, 2026
Sponsor: Sun Yat-sen University
Advanced/Metastatic Breast Cancer · HER2+, Low, or Ultralow Advanced/Metastatic Breast Cancer
China
A Trial to Find Out if Odronextamab Combined With Lenalidomide is Safe and Works Better Than Rituximab Combined With Lenalidomide in Adult Participants With Follicular Lymphoma and Marginal Zone LymphomaRecruiting
NCT06149286Phase 3Updated Aug 14, 2026
Sponsor: Regeneron Pharmaceuticals
Relapsed/Refractory Follicular Lymphoma · Relapsed/Refractory Marginal Zone Lymphoma (R/R MZL)
United States, Australia, Austria, Belgium, Brazil +13 more
Neoadjuvant and Adjuvant Therapy Studies of Sintilimab Combined With Chemotherapy With or Without Ipilimumab N01 in Resectable Gastric/Gastroesophageal Junction AdenocarcinomaRecruiting
NCT07643623Phase 2, Phase 3Updated Aug 14, 2026
Sponsor: Innovent Biopharmaceutical Technology (Hangzhou) Co., LTD.
Resectable Gastric/Gastroesophageal Junction Adenocarcinoma
China
A Trial of SHR-A2102 With Adebrelimab in Locally Advanced or Metastatic Urothelial CarcinomaRecruiting
NCT07393542Phase 3Updated Aug 14, 2026
Sponsor: Suzhou Suncadia Biopharmaceuticals Co., Ltd.
Locally Advanced or Metastatic Urothelial Carcinoma
China
A Study of MK-8527 to Prevent Human Immunodeficiency Virus Type 1 (HIV-1) (MK-8527-010)Recruiting
NCT07071623Phase 3Updated Aug 14, 2026
Sponsor: Merck Sharp & Dohme LLC
Human Immunodeficiency Virus (HIV) · HIV Pre-Exposure Prophylaxis
Kenya, South Africa, Uganda
This Study Will Explore Whether a Combination of the Investigational Drug Mevrometostat (PF-06821497) and Enzalutamide Will Work Better Than Taking Enzalutamide Alone in Participants With mCSPC Who Are ARPI naïve.Recruiting
NCT07028853Phase 3Updated Aug 14, 2026
Sponsor: Pfizer
Metastatic Castration Sensitive Prostate Cancer (mCSPC) · Hormone Sensitive Prostate Cancer · Prostate Cancer · Cancer of the Prostate
United States, Argentina, Australia, Belgium, Brazil +21 more
A Phase 3 Study in India to Describe the Safety and Immunogenicity of RSVpreFRecruiting
NCT07653100Phase 3Updated Aug 14, 2026
Sponsor: Pfizer
Respiratory Syncytial Virus (RSV)
India

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