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A Study To Evaluate Pharmacokinetics, Efficacy, Safety, Tolerability, And Pharmacodynamics Of Satralizumab In Pediatric Patients With Aquaporin-4 Antibody Positive Neuromyelitis Optica Spectrum Disorder (NMOSD)Recruiting
NCT05199688Phase 3Updated Aug 11, 2026
Sponsor: Hoffmann-La Roche
Neuromyelitis Optica Spectrum Disorder · NMOSD
United States, Argentina, China, France, Italy +4 more
A Study to Investigate the Efficacy, Safety and Tolerability of Votoplam in Participants With Huntington's DiseaseRecruiting
NCT07326709Phase 3Updated Aug 11, 2026
Sponsor: Novartis Pharmaceuticals
Huntington Disease
United States, Argentina, Australia, Belgium, Canada +9 more
Anterior Iliopsoas Space Block Versus PENG Block on Ease of Positioning for Spinal Anathesia in Patients Undergoing Hip SurgeriesRecruiting
NCT07467356Phase 3Updated Aug 11, 2026
Sponsor: Benha University
Pain Management
Egypt
Combined Dose-Finding and CV Outcomes Study With CSL300 (Clazakizumab) in Adult Subjects With ESKD Undergoing Dialysis (POSIBIL6ESKD)Recruiting
NCT05485961Phase 2, Phase 3Updated Aug 11, 2026
Sponsor: CSL Behring
End Stage Kidney Disease
United States, Argentina, Australia, Austria, Belgium +30 more
Phase 2/3 Study of Participants With Recurrent Pericarditis Evaluating the Efficacy and Safety of KPL-387Recruiting
NCT07010159Phase 2, Phase 3Updated Aug 11, 2026
Sponsor: Kiniksa Pharmaceuticals International, plc
Pericarditis · Pericarditis Acute · Recurrent Pericarditis
United States, Canada, France, Germany, Greece +5 more
DESTINY-Endometrial01: A Phase III Study of Trastuzumab Deruxtecan Plus Rilvegostomig or Pembrolizumab as First-Line Treatment of HER2-Expressing (IHC 3+/2+), Mismatch Repair Proficient (pMMR) Endometrial CancerRecruiting
NCT06989112Phase 3Updated Aug 11, 2026
Sponsor: AstraZeneca
Endometrial Cancer
United States, Australia, Austria, Belgium, Brazil +18 more
Trauma Resuscitation With Low-Titer Group O Whole Blood or ProductsRecruiting
NCT05638581Phase 3Updated Aug 11, 2026
Sponsor: University of Alabama at Birmingham
Wounds and Injuries · Shock, Hemorrhagic
United States
Evaluate the Efficacy and Safety of HMI-115 in Women With Moderate to Severe Endometriosis-associated PainRecruiting
NCT07318688Phase 3Updated Aug 11, 2026
Sponsor: Hope Medicine (Nanjing) Co., Ltd
Endometriosis
China
A Study to Learn About the Safety and Effects of Salanersen (BIIB115) When Given to Babies With Spinal Muscular Atrophy (SMA) Who Were Previously Treated With Onasemnogene AbeparvovecRecruiting
NCT07444450Phase 3Updated Aug 11, 2026
Sponsor: Biogen
Muscular Atrophy, Spinal
United States
A Study to Investigate the Effects of Cleminorexton Compared With Placebo in the Treatment of Participants With Central Disorders of HypersomnolenceRecruiting
NCT07598708Phase 2, Phase 3Updated Aug 11, 2026
Sponsor: Centessa Pharmaceuticals (UK) Limited
Narcolepsy Type 1 · Narcolepsy Type 2
United States
Effects of Continued Administration of Empagliflozin in Patients With Heart Failure on Active SGLT2 Inhibitor Treatment Admitted for Acute Decompensated Heart FailureRecruiting
NCT07038356Phase 3Updated Aug 11, 2026
Sponsor: Christian Schulze
Acute Decompensated Heart Failure (ADHF)
Germany
Azithromycin for Critical Asthma - PediatricsRecruiting
NCT06223828Phase 2, Phase 3Updated Aug 11, 2026
Sponsor: Johns Hopkins All Children's Hospital
Pediatric Asthma · Critical Illness
United States
PRE-EMPT: Prospective RandomizEd Evaluation and Management of Premature aTherosclerosisRecruiting
NCT07232069Phase 3Updated Aug 11, 2026
Sponsor: Duke University
Coronary Artery Disease Risk Factors Multiple · Coronary Artery Disease Progression · Prevention & Control · Premature Atherosclerosis
United States
A Study to Investigate Efficacy & Safety of Intratumoral INT230-6 Compared to US Standard of Care in Adults With Soft Tissue Sarcomas (INVINCIBLE-3)Recruiting
NCT06263231Phase 3Updated Aug 11, 2026
Sponsor: Intensity Therapeutics, Inc.
Sarcoma,Soft Tissue
United States, Canada, France, Germany, Spain
A Study to Evaluate 20vPnC in Healthy Chinese InfantsRecruiting
NCT07754539Phase 3Updated Aug 10, 2026
Sponsor: Pfizer
Pneumococcal Diseases
China
A Study of Aleniglipron in Adults With Obesity or Overweight and Type 2 Diabetes Mellitus (ACCOMPLISH-2)Recruiting
NCT07654374Phase 3Updated Aug 10, 2026
Sponsor: Gasherbrum Bio, Inc., a wholly owned subsidiary of Structure Therapeutics
Obesity · Overweight · Chronic Weight Management · Type2 Diabetes Mellitus
United States
A Study to Evaluate the Efficacy of Pumitamig Versus Pembrolizumab in Participants With Previously Untreated Advanced Non-Small Cell Lung Cancer and PD-L1 ≥ 50%. (ROSETTA Lung-202)Recruiting
NCT07361510Phase 3Updated Aug 10, 2026
Sponsor: Bristol-Myers Squibb
Non-Small Cell Lung Cancer (NSCLC)
United States, Argentina, Australia, Austria, Belgium +31 more
NBI-1065845-MDD3026: Study to Assess the Efficacy and Safety of NBI-1065845 as an Adjunctive Treatment in Participants With Major Depressive Disorder (MDD)Recruiting
NCT06963021Phase 3Updated Aug 10, 2026
Sponsor: Neurocrine Biosciences
Major Depressive Disorder
United States, Belgium, Canada, Finland, Hungary +2 more
Platform Study of Circulating Tumor DNA Directed Adjuvant Chemotherapy in Colon Cancer (KCSG CO22-12)Recruiting
NCT05534087Phase 3Updated Aug 10, 2026
Sponsor: Seoul National University Hospital
Colon Cancer
South Korea
A Study of Izalontamab Brengitecan Versus Chemotherapy in Participants With Previously Untreated, Locally Advanced, Recurrent Inoperable, or Metastatic Triple-negative Breast Cancer Ineligible for Anti-PD(L)1 Drugs (IZABRIGHT-Breast01)Recruiting
NCT06926868Phase 2, Phase 3Updated Aug 10, 2026
Sponsor: Bristol-Myers Squibb
Breast Neoplasms
United States, Argentina, Australia, Austria, Brazil +23 more
A Study to Learn About the Safety and Effects of the Study Drug PRX-102 in Children and Adolescents With Fabry DiseaseRecruiting
NCT06328608Phase 2, Phase 3Updated Aug 10, 2026
Sponsor: Chiesi Farmaceutici S.p.A.
Fabry Disease
United States, Austria, France, Norway, Spain +1 more
A Study to Compare the Combination of Navlimetostat (BMS-986504) With Pembrolizumab and Chemotherapy Versus Placebo Plus Pembrolizumab and Chemotherapy in First-line Metastatic Non-small Cell Lung Cancer Participants With Homozygous MTAP DeletionRecruiting
NCT07063745Phase 2, Phase 3Updated Aug 10, 2026
Sponsor: Bristol-Myers Squibb
Metastatic Non-small Cell Lung Cancer With MTAP Deletion
United States, Argentina, Australia, Austria, Belgium +29 more
Modified DHAP Versus Standard DHAP in Relapsed/Refractory Diffused Large B-cell Lymphoma.Recruiting
NCT07739654Phase 3Updated Aug 10, 2026
Sponsor: King Edward Medical University
DLBCL - Diffuse Large B Cell Lymphoma
Pakistan
Vadadustat for the Treatment of Nonintubated Acute Respiratory Distress Syndrome Due to Pathogen-Associated Lung InjuryRecruiting
NCT07086755Phase 2, Phase 3Updated Aug 10, 2026
Sponsor: Paul Potnuru
Nonintubated Acute Respiratory Distress Syndrome (ARDS) · Pathogen-associated Lung Injury
United States
Phase Ⅲ Trial of Group ACYW135 Meningococcal Conjugate Vaccine in Children Aged 6-11 MonthsRecruiting
NCT07505823Phase 3Updated Aug 10, 2026
Sponsor: Sinovac Biotech Co., Ltd
Epidemic Meningitis · Meningococcal Vaccines
China

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