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Comparative Efficacy of Different Dentin Occluding Toothpaste TechnologiesRecruiting
NCT07664592Phase 3Updated Aug 7, 2026
Sponsor: Colgate Palmolive
Dentinal Sensitivity · Dentinal Hypersensitivity
Brazil
A Study to Evaluate the Effectiveness of IDCT (Intradiscal Cell Therapy) in Subjects With One Level, Symptomatic Mild to Moderate Lumbar Degenerative Disc DiseaseRecruiting
NCT07254806Phase 3Updated Aug 7, 2026
Sponsor: DiscGenics, Inc.
Degenerative Disc Disease
United States
A Study to Investigate Efficacy and Safety of Pegtibatinase Compared With Placebo in Participants ≥12 to ≤65 Years of Age With Classical Homocystinuria (HCU) Due to Cystathionine Beta Synthase Deficiency Receiving Standard of Care TreatmentRecruiting
NCT06247085Phase 3Updated Aug 7, 2026
Sponsor: Travere Therapeutics, Inc.
Homocystinuria
United States, Australia, Belgium, France, Germany +9 more
A Study to Evaluate the Efficacy and Safety of ALKS 2680 in Adults With Narcolepsy Type 2Recruiting
NCT07502443Phase 3Updated Aug 7, 2026
Sponsor: Alkermes, Inc.
Narcolepsy Type 2
United States, Belgium, Canada, France, Italy +2 more
A Study to Investigate Tislelizumab Administered as Subcutaneous Injection Versus Intravenous Infusion Plus Chemotherapy in Patients With Unresectable or Metastatic Gastric or Gastroesophageal Junction AdenocarcinomaRecruiting
NCT07043400Phase 3Updated Aug 7, 2026
Sponsor: BeOne Medicines
Metastatic Gastric Adenocarcinoma · Gastroesophageal Junction Adenocarcinoma
United States, Argentina, Austria, Brazil, China +11 more
A Study of Nemtabrutinib (MK-1026) Versus Comparator (Investigator's Choice of Ibrutinib or Acalabrutinib) in First Line (1L) Chronic Lymphocytic Leukemia (CLL)/ Small Lymphocytic Lymphoma (SLL) (MK-1026-011/BELLWAVE-011)Recruiting
NCT06136559Phase 3Updated Aug 7, 2026
Sponsor: Merck Sharp & Dohme LLC
Chronic Lymphocytic Leukemia · Small Lymphocytic Lymphoma
United States, Australia, Belgium, Brazil, Canada +24 more
A Study of Dulaglutide (LY2189265) 3.0 mg and 4.5 mg in Pediatric Participants With Type 2 Diabetes Mellitus (AWARD-PEDS PLUS)Recruiting
NCT06739122Phase 3Updated Aug 7, 2026
Sponsor: Eli Lilly and Company
Type 2 Diabetes
United States, Argentina, Mexico
A Study to Investigate Efficacy and Safety of PT027 Compared With PT007 in Symptomatic Chinese Adults With AsthmaRecruiting
NCT06471257Phase 3Updated Aug 7, 2026
Sponsor: AstraZeneca
Asthma
China, Hong Kong
A Clinical Study of Sacituzumab Tirumotecan (MK-2870) in Combination With Pembrolizumab (MK-3475) as First-line Maintenance Treatment of Cervical Cancer (MK-2870-036/TroFuse-036/GOG-3123/ENGOT-cx22)Recruiting
NCT07216703Phase 3Updated Aug 7, 2026
Sponsor: Merck Sharp & Dohme LLC
Cervical Cancer
United States, Argentina, Austria, Belgium, Brazil +22 more
A Double-blind, Randomized Controlled Trial to Investigate the Efficacy, Safety, and Pharmacokinetics of Pegloticase Administration Via Subcutaneous and Intravenous Routes Both With Methotrexate in Participants With Uncontrolled GoutRecruiting
NCT07388498Phase 3Updated Aug 7, 2026
Sponsor: Amgen
Uncontrolled Gout
United States, Puerto Rico
Lp(a) Lowering Study of Pelacarsen (TQJ230) With Background Inclisiran in Participants With Elevated Lp(a) and Established ASCVDRecruiting
NCT06813911Phase 3Updated Aug 7, 2026
Sponsor: Novartis Pharmaceuticals
Atherosclerotic Cardiovascular Disease (ASCVD)
United States, China, France, Germany, Hong Kong +6 more
A Study of Mezagitamab in Adults With Chronic Primary Immune ThrombocytopeniaRecruiting
NCT06722235Phase 3Updated Aug 7, 2026
Sponsor: Takeda
Immune Thrombocytopenic Purpura (ITP)
United States, Australia, Bulgaria, China, Croatia +13 more
A Phase 3 Randomized Clinical Trial to Investigate the Safety and Efficacy of Palopegteriparatide at Doses Greater Than 30 μg/Day in Adult Participants With HypoparathyroidismRecruiting
NCT07081997Phase 3Updated Aug 7, 2026
Sponsor: Ascendis Pharma Bone Diseases A/S
Hypoparathyroidism · Endocrine System Diseases · Parathyroid Diseases
United States
Standard-dose vs Intermediate-dose Cytarabine Induction in the Treatment of Acute Myeloid Leukemia With RUNX1-RUNX1T1Recruiting
NCT06744504Phase 3Updated Aug 7, 2026
Sponsor: Institute of Hematology & Blood Diseases Hospital, China
AML · RUNX1-RUNX1T1 Fusion Protein Expression
China
Osimertinib With or Without Primary Lung Tumor Resection for EGFR-Mutant Oligometastatic Non-Small Cell Lung CancerRecruiting
NCT07738172Phase 3Updated Aug 7, 2026
Sponsor: National Taiwan University Hospital
Lung Neoplasms, Non-Small Cell Lung Cancer
Taiwan
A Study to Evaluate the Efficacy and Safety of ALKS 2680 in Adults With Narcolepsy Type 1Recruiting
NCT07455383Phase 3Updated Aug 7, 2026
Sponsor: Alkermes, Inc.
Narcolepsy Type 1
United States, Australia, Belgium, Canada, France +1 more
Impact of Sentinel Lymph Node Mapping on Patient Reported Lower Extremity Limb Dysfunction in Stage I Endometrial CancerRecruiting
NCT05646316Phase 3Updated Aug 7, 2026
Sponsor: NRG Oncology
Stage I Uterine Corpus Carcinoma or Carcinosarcoma AJCC v8
United States, South Korea
A Master Protocol (AMAZ): A Study of Mirikizumab (LY3074828) in Pediatric Participants With Ulcerative Colitis or Crohn's Disease (SHINE-ON)Recruiting
NCT04844606Phase 3Updated Aug 7, 2026
Sponsor: Eli Lilly and Company
Ulcerative Colitis · Ulcerative Colitis Chronic · Inflammatory Bowel Diseases · Crohn's Disease
United States, Austria, Belgium, Brazil, Canada +11 more
A Study to Compare Setidegrasib (ASP3082) With Docetaxel, in People With Non-small Cell Lung Cancer With a KRAS G12D MutationRecruiting
NCT07566052Phase 3Updated Aug 7, 2026
Sponsor: Astellas Pharma Global Development, Inc.
Non-small Cell Lung Cancer (NSCLC)
United States, Japan
Testing Olaparib for One or Two Years, With or Without Bevacizumab, to Treat Ovarian CancerRecruiting
NCT06580314Phase 3Updated Aug 7, 2026
Sponsor: NRG Oncology
Fallopian Tube Endometrioid Adenocarcinoma · Fallopian Tube High Grade Serous Adenocarcinoma · Fallopian Tube Malignant Mixed Mesodermal (Mullerian) Tumor · FIGO Stage III Ovarian Cancer 2014
United States, Japan, Puerto Rico
Efficacy and Safety of CSL222 (Etranacogene Dezaparvovec) Gene Therapy in Adults With Hemophilia B With Pretreatment Adeno-associated Virus Serotype 5 (AAV5) Neutralizing Antibodies (Nabs)Recruiting
NCT06003387Phase 3Updated Aug 7, 2026
Sponsor: CSL Behring
Hemophilia B
United States, Australia, Brazil, Bulgaria, Canada +10 more
Study of Olomorasib (LY3537982) in Combination With Standard of Care in Participants With Resected or Unresectable KRAS G12C-mutant Non-Small Cell Lung CancerRecruiting
NCT06890598Phase 3Updated Aug 7, 2026
Sponsor: Eli Lilly and Company
Carcinoma, Non-Small-Cell Lung
United States, Australia, Austria, Belgium, Brazil +24 more
Study to Assess the Pharmacokinetics, Safety, and Tolerability of Iptacopan in Pediatric PNH PatientsRecruiting
NCT06934967Phase 3Updated Aug 7, 2026
Sponsor: Novartis Pharmaceuticals
Paroxysmal Nocturnal Hemoglobinuria (PNH)
United States, Brazil, Colombia, Germany, Italy +1 more
Study to Determine if BHV-1300 is Effective and Safe in Adults With Graves' DiseaseRecruiting
NCT07661056Phase 3Updated Aug 7, 2026
Sponsor: Biohaven Therapeutics Ltd.
Graves Disease
United States
Zanzalintinib Versus Everolimus in Participants With Locally Advanced or Metastatic Neuroendocrine TumorsRecruiting
NCT06943755Phase 2, Phase 3Updated Aug 7, 2026
Sponsor: Exelixis
Pancreatic Neuroendocrine Tumor (pNET) · Extra-Pancreatic Neuroendocrine Tumor (epNET)
United States, Australia, Austria, Belgium, Canada +10 more

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