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A Study to Evaluate the Safety and Efficacy of Oral Nizubaglustat (AZ-3102) in Late-infantile and Juvenile Forms of Niemann-Pick Type C Disease (NPC)Recruiting
NCT07082725Phase 3Updated Aug 17, 2026
Sponsor: Azafaros B.V.
Niemann-Pick Type C Disease
United States, Argentina, Australia, Brazil, Canada +10 more
Gemcitabine Versus Water Irrigation in Upper Tract Urothelial CarcinomaRecruiting
NCT04865939Phase 3Updated Aug 17, 2026
Sponsor: University of Texas Southwestern Medical Center
Urothelial Cancer of Renal Pelvis · Urothelial Carcinoma Ureter
United States
A Study of Lebrikizumab in Adults With Nummular EczemaRecruiting
NCT07542483Phase 3Updated Aug 17, 2026
Sponsor: Almirall, S.A.
Nummular Eczema
Germany
A Study to Compare the Efficacy of Nivolumab and Relatlimab Plus Chemotherapy vs Pembrolizumab Plus Chemotherapy for Stage IV/Recurrent Non-squamous Non-small Cell Lung Cancer With PD-L1 Expression ≥ 1%Recruiting
NCT06561386Phase 3Updated Aug 17, 2026
Sponsor: Bristol-Myers Squibb
Non-small Cell Lung Cancer
United States, Argentina, Australia, Austria, Belgium +26 more
Symbiotic-GI-03: A Study to Learn About the Study Medicine Called PF-08634404 in Combination With Chemotherapy in Adult Participants With Metastatic Colorectal CancerRecruiting
NCT07222800Phase 3Updated Aug 17, 2026
Sponsor: Pfizer
Intestinal Neoplasms · Gastrointestinal Neoplasms · Digestive System Neoplasms · Neoplasms by Site
United States, Argentina, Australia, Belgium, Brazil +12 more
A Study to Evaluate Efficacy, Safety, and Immunogenicity With ABP 938 8 mg Versus EYLEA® HD (Aflibercept) in Participants With Neovascular Age-related Macular DegenerationRecruiting
NCT07614776Phase 3Updated Aug 17, 2026
Sponsor: Amgen
Neovascular Age-related Macular Degeneration · nAMD
United States
A Study to Learn About the Study Medicine Called Berobenatide (PF-08653944) in People With Overweight or ObesityRecruiting
NCT07595549Phase 3Updated Aug 17, 2026
Sponsor: Pfizer
Obesity · Overweight and/or Obesity · Overweight
United States, Brazil, Canada, Japan
Comparing Radiation Plus Cetuximab to Radiation Plus Chemotherapy in People With Head and Neck Cancer Who Cannot Receive CisplatinRecruiting
NCT07441681Phase 3Updated Aug 17, 2026
Sponsor: NRG Oncology
Clinical Stage I HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8 · Clinical Stage II HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8 · Clinical Stage III HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8 · Head and Neck Squamous Cell Carcinoma
United States
A Study to Investigate GB-0895 Adjunctive Therapy in Adults and Adolescents With Severe Uncontrolled Asthma (SOLAIRIA-1)Recruiting
NCT07276724Phase 3Updated Aug 17, 2026
Sponsor: Generate Biomedicines
Severe Asthma
United States, Bulgaria, Germany, Hungary, Latvia +4 more
A Phase 3 Study of Ersodetug in Patients With Tumor HyperinsulinismRecruiting
NCT06881992Phase 3Updated Aug 17, 2026
Sponsor: Rezolute
Tumor Hyperinsulinism (Tumor HI)
United States, France, Netherlands, Switzerland, United Kingdom
A Study Evaluating Adherence, Tolerability, and Patient Reported Outcomes of Giredestrant in Participants With ER+/HER2- Early Breast Cancer Who Are Intolerant to Adjuvant Aromatase Inhibitor Therapy (novERA Breast Cancer)Recruiting
NCT07541079Phase 3Updated Aug 17, 2026
Sponsor: Genentech, Inc.
Early Breast Cancer
United States
Open-label Extension Study of Zigakibart in Adults With IgA Nephropathy.Recruiting
NCT06858319Phase 3Updated Aug 17, 2026
Sponsor: Novartis Pharmaceuticals
Kidney Diseases · Kidney Diseases, Chronic · Urological Diseases · Glomerulonephritis
United States, Argentina, Australia, Canada, Malaysia +4 more
Testing Immunotherapy With or Without Stereotactic Body Radiation Therapy in Patients With Advanced Liver Cancer, HELIO-RT TrialRecruiting
NCT07166406Phase 3Updated Aug 17, 2026
Sponsor: NRG Oncology
Advanced Hepatocellular Carcinoma · Stage III Hepatocellular Carcinoma AJCC v8 · Stage IV Hepatocellular Carcinoma AJCC v8
United States, Canada
Comparing Sentinel Lymph Node (SLN) Biopsy With Standard Neck Dissection for Patients With Early-Stage Oral Cavity CancerRecruiting
NCT04333537Phase 2, Phase 3Updated Aug 17, 2026
Sponsor: NRG Oncology
Buccal Mucosa Squamous Cell Carcinoma · Floor of Mouth Squamous Cell Carcinoma · Gingival Squamous Cell Carcinoma · Hard Palate Squamous Cell Carcinoma
United States, Canada
A Study of Elacestrant Versus Standard Endocrine Therapy in Women and Men With ER+,HER2-, Early Breast Cancer With High Risk of RecurrenceRecruiting
NCT06492616Phase 3Updated Aug 17, 2026
Sponsor: Stemline Therapeutics, Inc.
Breast Cancer
United States, Argentina, Australia, Austria, Belgium +23 more
A Study of ZL-1310 Versus Investigator's Choice of Therapy in Participants With Relapsed Small Cell Lung Cancer (DLLEVATE)Recruiting
NCT07218146Phase 3Updated Aug 17, 2026
Sponsor: Zai Lab (Shanghai) Co., Ltd.
Small-cell Lung Cancer
United States, Austria, Belgium, China, France +8 more
DETERMINE Trial Treatment Arm 07: Dabrafenib in Combination With Trametinib in Adult, Paediatric and Teenage/Young Adult Patients With BRAF V600 Mutation-Positive Cancers.Recruiting
NCT07440290Phase 2, Phase 3Updated Aug 17, 2026
Sponsor: Cancer Research UK
Haematological Malignancy · Malignant Neoplasm · Lymphoproliferative Disorders · Neoplasms by Histologic Type
United Kingdom
Descemet Endothelial Thickness Comparison Trial IIRecruiting
NCT05275972Phase 3Updated Aug 17, 2026
Sponsor: Stanford University
Fuchs · Fuchs Dystrophy · Fuchs' Endothelial Dystrophy
United States
RESET-SSc: An Open-Label Study to Evaluate the Safety and Efficacy of CABA-201, a CD19-CAR T Cell Therapy, in Subjects With Systemic SclerosisRecruiting
NCT06328777Phase 2, Phase 3Updated Aug 17, 2026
Sponsor: Cabaletta Bio
Systemic Sclerosis · Scleroderma · Interstitial Lung Diseases
United States
Testing Proton Craniospinal Radiation Therapy Versus the Usual Radiation Therapy for Leptomeningeal Metastasis, RADIATE-LM TrialRecruiting
NCT06500481Phase 3Updated Aug 17, 2026
Sponsor: NRG Oncology
Anatomic Stage IV Breast Cancer AJCC v8 · Metastatic Breast Carcinoma · Metastatic Lung Non-Small Cell Carcinoma · Metastatic Malignant Neoplasm in the Leptomeninges
United States
A Study of Efficacy and Safety of Depemokimab Compared With Placebo in Adults and Adolescents With at Risk Type 2 AsthmaRecruiting
NCT07456033Phase 3Updated Aug 17, 2026
Sponsor: GlaxoSmithKline
Asthma
United States, United Kingdom
A Trial of the Efficacy and Safety of a Fixed Dose of SEP-363856 in Adults With Generalized Anxiety DisorderRecruiting
NCT07767903Phase 3Updated Aug 17, 2026
Sponsor: Otsuka Pharmaceutical Development & Commercialization, Inc.
Generalized Anxiety Disorder
United States
PREcision MEDicine In Achalasia (PREMEDIA)Recruiting
NCT07293650Phase 3Updated Aug 17, 2026
Sponsor: Northwestern University
Type I Achalasia · Type II Achalasia · EGJ Outflow Obstruction Without Spastic/Hypercontractile Features
United States
A Study to Evaluate the Safety and Efficacy of Pumitamig in Combination With Chemotherapy Versus Bevacizumab in Combination With Chemotherapy in Participants With Previously Untreated, Unresectable, or Metastatic Colorectal CancerRecruiting
NCT07221357Phase 2, Phase 3Updated Aug 17, 2026
Sponsor: Bristol-Myers Squibb
Untreated, Unresectable, or Metastatic Colorectal Cancer
United States, Argentina, Australia, Austria, Belgium +21 more
Tranexamic Acid for Anaemia TrialRecruiting
NCT06519422Phase 3Updated Aug 17, 2026
Sponsor: London School of Hygiene and Tropical Medicine
Anaemia
Nigeria, Pakistan, Tanzania

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