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A Study to Investigate the Efficacy and Safety of Fitusiran Prophylaxis in Male Participants Aged 1 to Less Than 12 Years With Hemophilia A or BRecruiting
NCT07285460Phase 3Updated Aug 17, 2026
Sponsor: Sanofi
Hemophilia
United States, Belgium, Brazil, Canada, China +8 more
A Study of Enpatoran in Participants With Cutaneous Manifestations of Lupus With or Without Systemic Disease (ELOWEN-2)Recruiting
NCT07355218Phase 3Updated Aug 17, 2026
Sponsor: EMD Serono Research & Development Institute, Inc.
Systematic Lupus Erythematosus · Cutaneous Lupus Erythematosus
United States, Canada, China, Germany, Switzerland
Testing the Addition of High Dose, Targeted Radiation to the Usual Treatment for Locally-Advanced Inoperable Non-Small Cell Lung CancerRecruiting
NCT05624996Phase 3Updated Aug 17, 2026
Sponsor: NRG Oncology
Locally Advanced Lung Non-Small Cell Carcinoma · Stage IIB Lung Cancer AJCC v8 · Stage III Lung Cancer AJCC v8
United States, Canada
Investigating the Safety and Diagnostic Performance of 68Ga-NYM032 Injection PET/CT in Men With Newly Diagnosed Prostate Cancer.Recruiting
NCT07615101Phase 3Updated Aug 17, 2026
Sponsor: Norroy Bioscience Co., LTD
Prostate Cancer (Diagnosis)
China
Symbiotic-Lung-04: A Study to Learn About the Study Medicine Called PF-08634404 in Combination With Chemotherapy in Adult Participants With Extensive-Stage Small Cell Lung CancerRecruiting
NCT07226999Phase 2, Phase 3Updated Aug 17, 2026
Sponsor: Pfizer
Small Cell Lung Cancer (SCLC)
United States, Australia, China, France, Germany +5 more
AMAZE 6: A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight and Knee Osteoarthritis Lose Weight and Reduce PainRecruiting
NCT07509307Phase 3Updated Aug 17, 2026
Sponsor: Novo Nordisk A/S
Obesity · Overweight · Osteoarthritis, Knee
United States, Australia, Bulgaria, Canada, Denmark +6 more
A Study of Pirtobrutinib (LOXO-305) Versus Ibrutinib in Participants With Chronic Lymphocytic Leukemia (CLL)/Small Lymphocytic Lymphoma (SLL)Recruiting
NCT05254743Phase 3Updated Aug 17, 2026
Sponsor: Loxo Oncology, Inc.
Chronic Lymphocytic Leukemia · Leukemia, Lymphocytic · Leukemia, B-cell · Small Lymphocytic Lymphoma
United States, Argentina, Australia, Austria, Belgium +18 more
A Study to Investigate the Efficacy and Safety of Tezepelumab Compared With Placebo in Children 5 to < 12 Years Old With Severe AsthmaRecruiting
NCT06023589Phase 3Updated Aug 17, 2026
Sponsor: AstraZeneca
Asthma
United States, Argentina, Brazil, Canada, China +17 more
A Study to Learn About the Study Medicine Called PF-08046054/SGN-PDL1V Versus Docetaxel in Adult Participants With Previously-Treated Programmed Cell Death Ligand 1 (PD-L1) Positive Non-Small-Cell Lung Cancer (NSCLC)Recruiting
NCT07144280Phase 3Updated Aug 17, 2026
Sponsor: Pfizer
Non-small Cell Carcinoma · Non-Small Cell Lung Cancer Metastatic · Non-Small Cell Lung Carcinoma
United States, Argentina, Australia, Belgium, Brazil +24 more
Palazestrant in Combination With Ribociclib for the First-line Treatment of ER+/HER2- Advanced Breast CancerRecruiting
NCT07085767Phase 3Updated Aug 17, 2026
Sponsor: Olema Pharmaceuticals, Inc.
Breast Cancer · Locally Advanced Breast Cancer · Metastatic Breast Cancer · ER Positive Breast Cancer
United States, Australia, Austria, Belgium, Canada +18 more
Belantamab Mafodotin or Daratumumab With Bortezomib, Lenalidomide and Dexamethasone for Newly Diagnosed Multiple MyelomaRecruiting
NCT07285239Phase 3Updated Aug 17, 2026
Sponsor: PrECOG, LLC.
Multiple Myeloma
United States
Study of Intralesional Cemiplimab in Adult Patients With Early Stage Cutaneous Squamous Cell CarcinomaRecruiting
NCT06585410Phase 3Updated Aug 17, 2026
Sponsor: Regeneron Pharmaceuticals
Cutaneous Squamous Cell Carcinoma (CSCC)
United States, Australia
A Phase 3 Efficacy and Safety Study of Fosmanogepix for the Treatment of Adult Patients With Invasive Mold Infections.Recruiting
NCT06925321Phase 3Updated Aug 17, 2026
Sponsor: Basilea Pharmaceutica
Invasive Mold Infections
United States, Australia, Austria, Belgium, Brazil +10 more
Beclometasone Dipropionate and Formoterol Inhalation Aerosol for AsthmaRecruiting
NCT07768891Phase 3Updated Aug 17, 2026
Sponsor: Lunan Better Pharmaceutical Co., LTD.
Asthma (Diagnosis)
China
A Study of a Deuterated Psilocin Analog (CYB003) in Humans With Major Depressive DisorderRecruiting
NCT06793397Phase 3Updated Aug 17, 2026
Sponsor: Cybin IRL Limited
Major Depressive Disorder (MDD) · Depression in Adults · Depression - Major Depressive Disorder · Depression Disorders
United States, Australia, Czechia, Germany, Greece +3 more
A Study Investigating Subcutaneously Administered Pozelimab in Combination With Cemdisiran or Cemdisiran Alone in Adult Participants With Geographic AtrophyRecruiting
NCT06541704Phase 3Updated Aug 17, 2026
Sponsor: Regeneron Pharmaceuticals
Age-related Macular Degeneration (AMD) · Geographic Atrophy (GA)
United States, Australia, Austria, Canada, France +6 more
A Phase 3 Study to Evaluate the Safety and Efficacy of AOC 1044 (Also Referred to as Delpacibart Zotadirsen) in Participants With DMD With Gene Mutations Amenable to Exon 44 SkippingRecruiting
NCT07587242Phase 3Updated Aug 17, 2026
Sponsor: Avidity Biosciences, Inc.
Muscular Dystrophies · Muscular Dystrophies (Duchenne, Becker, Myotonic Dystrophy) · Muscular Disorders, Atrophic · Muscular Disease
Belgium, France, Germany, Italy, Spain +1 more
MK-3475A±Calderasib (MK-1084) in Completely Resected Stage IIA-IIIB (N2) KRAS G12Cm NSCLC (MK-1084-013)Recruiting
NCT07431827Phase 3Updated Aug 17, 2026
Sponsor: Merck Sharp & Dohme LLC
Non-small Cell Lung Cancer
Argentina, Australia, Brazil, Canada, Chile +10 more
Study of the Bria-IMT Regimen and CPI vs Physicians' Choice in Advanced Metastatic Breast Cancer.Recruiting
NCT06072612Phase 3Updated Aug 17, 2026
Sponsor: BriaCell Therapeutics Corporation
Breast Cancer · Metastatic Breast Cancer · Breast Neoplasm · Breast Cancer Metastatic
United States
Evaluate the Concordance Between PET Imaging of [18F]-APN-1607 Injection and Postmortem Brain Tissue Tau Pathology in Individuals With HV and MCI or AD.Recruiting
NCT07752784Phase 3Updated Aug 17, 2026
Sponsor: JYAMS PET Research & Development Limited
Alzheimer's Disease
China
A Study of the Medicine Called Abrocitinib in Children 6 to Less Than 12 Years of Age With Moderate-to-Severe EczemaRecruiting
NCT06807268Phase 3Updated Aug 17, 2026
Sponsor: Pfizer
Eczema
United States, China, Germany, Hungary, Japan +3 more
A Study to Assess Efficacy and Safety of KarXT for the Treatment of Psychosis Associated With Alzheimer's Disease (ADEPT-1)Recruiting
NCT05511363Phase 3Updated Aug 17, 2026
Sponsor: Karuna Therapeutics, Inc., a Bristol Myers Squibb company
Psychosis Associated With Alzheimer's Disease
United States, Bulgaria, Croatia, Czechia, France +8 more
Testing if High Dose Radiation Only to the Sites of Brain Cancer Compared to Whole Brain Radiation That Avoids the Hippocampus is Better at Preventing Loss of Memory and Thinking AbilityRecruiting
NCT04804644Phase 3Updated Aug 17, 2026
Sponsor: NRG Oncology
Metastatic Lung Small Cell Carcinoma · Metastatic Malignant Neoplasm in the Brain · Recurrent Lung Small Cell Carcinoma · Stage IV Lung Cancer AJCC v8
United States, Canada
Symbiotic-GI-16: A Study to Learn About the Study Medicine Called PF-08634404 in Combination With Chemotherapy in Gastroesophageal CancerRecruiting
NCT07392892Phase 2, Phase 3Updated Aug 17, 2026
Sponsor: Pfizer
Untreated Advanced or Metastatic Gastric, Gastroesophageal Junction , or Esophageal Adenocarcinoma · Metastatic Gastric Cancer · Gastroesophageal Junction Cancer · Esophageal Adenocarcinoma
United States, China, Israel, Italy, Japan +3 more
A Phase 3 Study of Fenfluramine Hydrochloride in Rett SyndromeRecruiting
NCT07503444Phase 3Updated Aug 17, 2026
Sponsor: UCB BIOSCIENCES, Inc.
Rett Syndrome
United States, Belgium, France, Hungary, Italy +3 more

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