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Results for “Roche”

A Study Evaluating the Safety, Pharmacokinetics, and Efficacy of Mosunetuzumab or Glofitamab in Combination With CC-220 and/or CC-99282 in Participants With B-Cell Non-Hodgkin LymphomaActive Not Recruiting
NCT05169515Phase 1Updated Aug 17, 2026
Sponsor: Hoffmann-La Roche
Non-Hodgkin Lymphoma
United States, Israel, Italy, Spain, United Kingdom
A Study to Investigate the Safety, Tolerability, and Pharmacokinetics of RO7663498 Following Intravitreal Administration in Participants With Diabetic RetinopathyRecruiting
NCT07588100Phase 1Updated Aug 17, 2026
Sponsor: Hoffmann-La Roche
Diabetic Retinopathy
United States
A Study Evaluating the Safety and Efficacy of Targeted Therapies in Subpopulations of Patients With Metastatic Colorectal Cancer (INTRINSIC)Recruiting
NCT04929223Phase 1Updated Aug 17, 2026
Sponsor: Hoffmann-La Roche
Metastatic Colorectal Cancer
United States, Australia, Canada, Denmark, Germany +6 more
Study of Zifibancimig in Participants With Neovascular Age-related Macular DegenerationActive Not Recruiting
NCT04567303Phase 1, Phase 2Updated Aug 14, 2026
Sponsor: Hoffmann-La Roche
Macular Degeneration
United States, Puerto Rico
A Study to Evaluate the Optimization of the Cytokine Release Syndrome Profile for Glofitamab in Combination With Gemcitabine Plus Oxaliplatin in Participants With Relapsed/Refractory Aggressive B-Cell Non-Hodgkin's LymphomaRecruiting
NCT06806033Phase 2Updated Aug 14, 2026
Sponsor: Hoffmann-La Roche
B-Cell Non-Hodgkins Lymphoma
United States, Australia, Canada, France, Germany +2 more
A Study to Evaluate the Pharmacokinetics, Safety and Efficacy of Afimkibart (RO7790121) in Children With Moderately to Severely Active Ulcerative ColitisRecruiting
NCT07158242Phase 3Updated Aug 14, 2026
Sponsor: Hoffmann-La Roche
Moderately to Severely Active Ulcerative Colitis
United States, Australia, Brazil, Canada, China +4 more
A Study to Evaluate the Efficacy and Safety of Sefaxersen (RO7434656) in Participants With Primary Immunoglobulin A (IgA) Nephropathy at High Risk of ProgressionActive Not Recruiting
NCT05797610Phase 3Updated Aug 14, 2026
Sponsor: Hoffmann-La Roche
Primary IgA Nephropathy
United States, Argentina, Australia, Brazil, Canada +16 more
A Clinical Study to Evaluate the Effects of Enicepatide (RO7795068) in Participants With Obesity or Overweight and Type 2 DiabetesRecruiting
NCT07351058Phase 3Updated Aug 14, 2026
Sponsor: Hoffmann-La Roche
Obesity or Overweight · Type 2 Diabetes Mellitus
United States, Argentina, Australia, Brazil, Canada +15 more
A Study Evaluating the Efficacy and Safety of Multiple Immunotherapy-Based Treatment Combinations in Patients With Advanced Liver Cancers (Morpheus-Liver)Recruiting
NCT04524871Phase 1, Phase 2Updated Aug 14, 2026
Sponsor: Hoffmann-La Roche
Advanced Liver Cancers
United States, China, France, Israel, New Zealand +2 more
A Study to Evaluate ALN-AGT01 RVR in Adult Patients With Mild to Moderate Hypertension Pretreated With ZilebesiranRecruiting
NCT07553442Phase 2Updated Aug 14, 2026
Sponsor: Alnylam Pharmaceuticals
Hypertension
United States
A Study to Evaluate the Long-Term Safety of Astegolimab in Participants With Chronic Obstructive Pulmonary Disease (COPD)Active Not Recruiting
NCT05878769Phase 3Updated Aug 14, 2026
Sponsor: Hoffmann-La Roche
Chronic Obstructive Pulmonary Disease
United States, Argentina, Australia, Austria, Belgium +35 more
A Study Evaluating the Safety, Pharmacokinetics, and Efficacy of Alectinib in Pediatric Participants With ALK Fusion-Positive Solid or CNS TumorsActive Not Recruiting
NCT04774718Phase 1, Phase 2Updated Aug 14, 2026
Sponsor: Hoffmann-La Roche
ALK Fusion-positive Solid or CNS Tumors
United States, Australia, Brazil, Canada, China +6 more
Cevostamab in Combination With Pomalidomide and Dexamethasone Versus Standard of Care in Participants With Previously Treated Multiple MyelomaRecruiting
NCT07555938Phase 3Updated Aug 14, 2026
Sponsor: Hoffmann-La Roche
Multiple Myeloma
United States, Canada, Germany, Greece, Israel +6 more
A Clinical Study to Evaluate the Effects of Enicepatide (RO7795068) in Participants With Obesity or Overweight Without Type 2 DiabetesRecruiting
NCT07351045Phase 3Updated Aug 14, 2026
Sponsor: Hoffmann-La Roche
Obesity or Overweight
United States, Argentina, Australia, Belgium, Brazil +15 more
A Study to Compare the Efficacy and Safety of Entrectinib and Crizotinib in Participants With Advanced or Metastatic ROS1 Non-small Cell Lung Cancer (NSCLC) With and Without Central Nervous System (CNS) MetastasesActive Not Recruiting
NCT04603807Phase 3Updated Aug 13, 2026
Sponsor: Hoffmann-La Roche
Carcinoma, Non-Small-Cell Lung
Brazil, China, Croatia, France, Germany +13 more
A Study Investigating the Outcomes and Safety of Atezolizumab Under Real-World Conditions in Patients Treated in Routine Clinical PracticeCompleted
NCT03782207N/AUpdated Aug 13, 2026
Sponsor: Hoffmann-La Roche
Urothelial Carcinoma · Non-Small Cell Lung Cancer · Small Cell Lung Cancer · Hepatocellular Carcinoma
Argentina, Austria, Belgium, Brazil, Bulgaria +25 more
A Study of Participants in China With Non-Small-Cell Lung Cancer That is Unable to be Treated With SurgeryCompleted
NCT05872763N/AUpdated Aug 13, 2026
Sponsor: Hoffmann-La Roche
Carcinoma, Non-Small-Cell Lung
China
A Study to Evaluate the Efficacy and Safety of Fenebrutinib Compared With Teriflunomide in Relapsing Multiple Sclerosis (RMS)Active Not Recruiting
NCT04586010Phase 3Updated Aug 13, 2026
Sponsor: Hoffmann-La Roche
Relapsing Multiple Sclerosis
United States, Argentina, China, Dominican Republic, Finland +18 more
A Study to Investigate the Safety, Tolerability, Pharmacokinetics, Immunogenicity, and Pharmacodynamics of a New Subcutaneous Formulation of Ocrelizumab in Participants With Multiple SclerosisActive Not Recruiting
NCT07667322Phase 1Updated Aug 13, 2026
Sponsor: Hoffmann-La Roche
Multiple Sclerosis
United States, Brazil, Mexico, United Kingdom
Safety,Tolerability, Pharmacokinetics, and Efficacy of YL211 in Patients With Advanced Solid TumorsRecruiting
NCT06384352Phase 1Updated Aug 13, 2026
Sponsor: MediLink Therapeutics (Suzhou) Co., Ltd.
Advanced Solid Tumors
United States, Australia, Canada, China
A Study to Investigate Effects of Ocrelizumab Treatment on Neurofilament Light Chain (NfL) Levels and Participant Satisfaction in Participants With Multiple Sclerosis (MS)Recruiting
NCT06780150N/AUpdated Aug 13, 2026
Sponsor: Hoffmann-La Roche
Multiple Sclerosis
Germany, Switzerland
A Study to Evaluate the Effects of Enicepatide in Participants With Obesity or Overweight, With or Without Type 2 DiabetesRecruiting
NCT07670416Phase 3Updated Aug 13, 2026
Sponsor: Hoffmann-La Roche
Obesity · Overweight · Type 2 Diabetes Mellitus (T2DM)
China
A Study to Assess the Efficacy and Safety of Satralizumab in Duchenne Muscular Dystrophy (DMD)Active Not Recruiting
NCT06450639Phase 2Updated Aug 13, 2026
Sponsor: Hoffmann-La Roche
Duchenne Muscular Dystrophy
United States, Denmark, Italy, Poland, Spain +1 more
A Study to Investigate the Safety, Tolerability, and Processing by the Body of Intravenous and Subcutaneous RO7121932 Administration in Participants With Multiple SclerosisRecruiting
NCT05704361Phase 1Updated Aug 13, 2026
Sponsor: Hoffmann-La Roche
Multiple Sclerosis
United States, Belgium, Canada, Germany, Israel +7 more
A Study to Evaluate the Efficacy, Safety, Pharmacokinetics, and Pharmacodynamics of Satralizumab in Participants With Thyroid Eye DiseaseCompleted
NCT06106828Phase 3Updated Aug 12, 2026
Sponsor: Hoffmann-La Roche
Thyroid Eye Disease
United States, Canada, China, France, Israel +5 more

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