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Results for “Roche”

Effectiveness of a Multidisciplinary Medication Review With Follow-up for Patients Treated With Coumarin Anticoagulants in Primary CareCompleted
NCT03154489NAUpdated May 4, 2021
Sponsor: Universidad San Jorge
Anticoagulant · Pharmacogenetics · Community Pharmacy Services · Drug Utilization Review
Spain
Observational Study of Pertuzumab Safety in Participants With Breast CancerCompleted
NCT02266173N/AUpdated May 3, 2021
Sponsor: Hoffmann-La Roche
Breast Cancer
South Korea
A Safety and Tolerability Study of Assisted and Self-Administered Subcutaneous (SC) Herceptin (Trastuzumab) as Adjuvant Therapy in Early Human Epidermal Growth Factor Receptor 2 (HER2)-Positive Breast CancerCompleted
NCT01566721Phase 3Updated Apr 27, 2021
Sponsor: Hoffmann-La Roche
Breast Neoplasms
Albania, Algeria, Argentina, Australia, Bosnia and Herzegovina +54 more
Vemurafenib Plus Cobimetinib in Advanced or Metastatic Melanoma PatientsTerminated
NCT03224208Phase 2Updated Apr 26, 2021
Sponsor: Fondazione Melanoma Onlus
Melanoma · Melanoma (Skin) · Melanoma Stage
Italy
Evaluation of Response to the Neoadjuvant Chemotherapy for Advanced Ovarian Cancer by Multimodal Functional ImagingCompleted
NCT02792959NAUpdated Apr 21, 2021
Sponsor: Institut Bergonié
Ovarian Cancer
France
Therapy With Bevacizumab (BEV), Doxorubicin, and Cyclophosphamide Followed by BEV, Docetaxel, and Capecitabine Before Surgery Followed by BEV Alone After Surgery for Women With Locally Advanced Breast CancerCompleted
NCT00365417Phase 2Updated Apr 13, 2021
Sponsor: NSABP Foundation Inc
Breast Cancer
United States
A Study Evaluating the Safety of Tocilizumab in Addition to Standard of Care Premedication Given Before Obinutuzumab + Chlorambucil in Participants With Untreated B-Cell Chronic Lymphocytic Leukemia (B-CLL) and ComorbiditiesTerminated
NCT02336048Phase 1Updated Apr 8, 2021
Sponsor: Hoffmann-La Roche
B-Cell Chronic Lymphocytic Leukemia
Israel, Italy, Latvia, Spain, United Kingdom
A Study of Atezolizumab (Anti-Programmed Death-Ligand 1 [PD-L1] Antibody) Alone or in Combination With an Immunomodulatory Drug and/or Daratumumab in Participants With Multiple Myeloma (MM)Completed
NCT02431208Phase 1Updated Apr 2, 2021
Sponsor: Hoffmann-La Roche
Multiple Myeloma
United States
A Study of Trastuzumab Emtansine in Indian Patients With Human Epidermal Growth Factor Receptor 2 (HER2)-Positive Unresectable Locally Advanced or Metastatic Breast Cancer Who Have Received Prior Treatment With Trastuzumab and a TaxaneCompleted
NCT02658734Phase 4Updated Apr 2, 2021
Sponsor: Hoffmann-La Roche
HER2 Positive Breast Cancer, Metastatic Breast Cancer, Locally Advanced Breast Cancer
India
A Study to Characterize the Disease Behavior of Idiopathic Pulmonary Fibrosis (IPF) and Interstitial Lung Disease (ILD) During the Peri-Diagnostic PeriodCompleted
NCT03261037NAUpdated Mar 26, 2021
Sponsor: Hoffmann-La Roche
Idiopathic Pulmonary Fibrosis · Interstitial Lung Disease
Canada, France, Ireland, Italy, Netherlands +1 more
A Study to Investigate the Effect of Esomeprazole and the Effect of Food on the Pharmacokinetics of Balovaptan in Healthy VolunteersCompleted
NCT04156646Phase 1Updated Mar 16, 2021
Sponsor: Hoffmann-La Roche
Autism Spectrum Disorder
United States
Sun May Arise on SMA : Newborn Screening of Spinal Muscular Atrophy in BelgiumCompleted
NCT03554343N/AUpdated Mar 10, 2021
Sponsor: Centre Hospitalier Régional de la Citadelle
Spinal Muscular Atrophy
Belgium
A Study to Investigate the Effect of Hepatic Impairment on the Pharmacokinetics and Safety and Tolerability of a Single Oral Dose of Risdiplam Compared to Matched Healthy Participants With Normal Hepatic FunctionCompleted
NCT03920865Phase 1Updated Feb 21, 2021
Sponsor: Hoffmann-La Roche
Muscular Atrophy, Spinal
United States
A Study to Evaluate the Efficacy and Safety of Trastuzumab Emtansine in Combination With Atezolizumab or Atezolizumab-Placebo in Participants With Human Epidermal Growth Factor-2 (HER2) Positive Locally Advanced or Metastatic Breast Cancer (BC) Who Received Prior Trastuzumab and Taxane Based TherapyCompleted
NCT02924883Phase 2Updated Feb 17, 2021
Sponsor: Hoffmann-La Roche
Metastatic Breast Cancer
United States, Australia, Canada, Germany, Italy +4 more
Bevacizumab and Lomustine for Recurrent GBMCompleted
NCT01290939Phase 3Updated Feb 15, 2021
Sponsor: European Organisation for Research and Treatment of Cancer - EORTC
Glioblastoma Multiforme · Cognition Disorders · Disability Evaluation
Netherlands
Safety, Tolerability and Efficacy of Rapid Optimization, Helped by NT-proBNP testinG, of Heart Failure TherapiesUnknown
NCT03412201NAUpdated Feb 12, 2021
Sponsor: Heart Initiative
Heart Failure
Argentina, Austria, Colombia, France, Hungary +7 more
A Study to Evaluate the Effects of Basmisanil in Participants With Cognitive Impairment Associated With Schizophrenia (CIAS) Treated With AntipsychoticsCompleted
NCT02953639Phase 2Updated Feb 9, 2021
Sponsor: Hoffmann-La Roche
Schizophrenia
United States
A Study to Investigate the Efficacy and Safety of Balovaptan (RO5285119) in Participants With Autism Spectrum Disorder (ASD)Terminated
NCT02901431Phase 2Updated Feb 8, 2021
Sponsor: Hoffmann-La Roche
Autism Spectrum Disorder
United States
Docetaxel, Doxorubicin and Cyclophosphamide Versus Vinorelbine and Capecitabine in Patients Not Sufficiently / Sufficiently Responding as Preoperative Treatment of Locally Advanced or Operable Primary Breast CancerCompleted
NCT00544765Phase 3Updated Feb 4, 2021
Sponsor: GBG Forschungs GmbH
Breast Cancer
A Study of the Efficacy and Safety of RO7198457 in Combination With Atezolizumab Versus Atezolizumab Alone Following Adjuvant Platinum-Doublet Chemotherapy in Participants Who Are ctDNA Positive After Surgical Resection of Stage II-III Non-Small Cell Lung CancerWithdrawn
NCT04267237Phase 2Updated Feb 4, 2021
Sponsor: Hoffmann-La Roche
Non-small Cell Lung Cancer (NSCLC)
A Study of R1507 in Participants With Recurrent or Refractory SarcomaTerminated
NCT00642941Phase 2Updated Feb 3, 2021
Sponsor: Hoffmann-La Roche
Sarcoma
United States, Australia, Canada, France, Germany +6 more
Monitoring Alectinib Treatment by Detection of ALK Translocations in Serial Blood Samples From Non-Small Cell Lung Cancer PatientsUnknown
NCT04708639N/AUpdated Feb 2, 2021
Sponsor: Aarhus University Hospital
Lung Cancer · ALK Gene Mutation · Resistance, Disease · Mutation
Denmark
Postoperative Adjuvant Chemotherapy With Bevacizumab and Maintenance Bevacizumab After Neoadjuvant Chemotherapy for Ovarian CancerCompleted
NCT02022917Phase 2Updated Jan 27, 2021
Sponsor: Chang Gung Memorial Hospital
Epithelial Ovarian Cancer
Taiwan
A Combination Study of Kadcyla (Trastuzumab Emtansine) and Capecitabine in Participants With Human Epidermal Growth Factor Receptor 2 (HER2)-Positive Metastatic Breast Cancer (mBC) or HER2-Positive Locally Advanced/Metastatic Gastric Cancer (LA/mGC)Terminated
NCT01702558Phase 2Updated Jan 22, 2021
Sponsor: Hoffmann-La Roche
Breast Cancer · Gastric Cancer
Argentina, Brazil, Canada, France, Germany +7 more
A Study of Pirfenidone in Patients With Unclassifiable Progressive Fibrosing Interstitial Lung DiseaseCompleted
NCT03099187Phase 2Updated Jan 13, 2021
Sponsor: Hoffmann-La Roche
Lung Diseases, Interstitial
Australia, Belgium, Canada, Czechia, Denmark +9 more

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