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Results for “Roche”

A Study to Determine Best Tumor Response With Trastuzumab Emtansine in Human Epidermal Growth Factor Receptor 2 (HER2) Overexpressing Solid TumorsCompleted
NCT02999672Phase 2Updated Aug 28, 2019
Sponsor: Hoffmann-La Roche
Bladder Cancer · Pancreas Cancer · Cholangiocellular Carcinoma
Italy, Netherlands, Slovakia, Spain
A Study to Detect V-Raf Murine Sarcoma Viral Oncogene Homolog B1 (BRAF) V600 Mutation on Cell-Free Deoxyribonucleic Acid (cfDNA) From Plasma in Participants With Advanced MelanomaCompleted
NCT02768207Phase 2Updated Aug 28, 2019
Sponsor: Hoffmann-La Roche
Metastatic Melanoma
Belgium, Poland
A Study of SC Administration of Trastuzumab (Herceptin) by SID at Home in HER2-Positive EBC ParticipantsCompleted
NCT02040935Phase 3Updated Aug 22, 2019
Sponsor: Hoffmann-La Roche
Breast Cancer
Netherlands
A Study to Assess All-Cause Mortality and Cardiovascular Morbidity in Participants With Chronic Kidney Disease (CKD) on Dialysis and Those Not on Renal Replacement Therapy Receiving Methoxy Polyethylene Glycol-Epoetin Beta (Mircera) or Reference Erythropoietin Stimulating Agents (ESAs)Completed
NCT00773513Phase 4Updated Aug 20, 2019
Sponsor: Hoffmann-La Roche
Chronic Renal Anemia
Argentina, Australia, Belgium, Brazil, Croatia +22 more
A Study of Disease Progression in Participants With Geographic Atrophy Secondary to Age-Related Macular DegenerationTerminated
NCT02479386N/AUpdated Aug 20, 2019
Sponsor: Hoffmann-La Roche
Geographic Atrophy
United States, Argentina, Australia, Austria, Brazil +10 more
A Study of Atezolizumab Administered Alone or in Combination With Azacitidine in Participants With Myelodysplastic SyndromesCompleted
NCT02508870Phase 1Updated Aug 19, 2019
Sponsor: Hoffmann-La Roche
Myelodysplastic Syndromes
United States
Peritoneal Dialysis in Congestive Heart FailureTerminated
NCT01124227Phase 3Updated Aug 16, 2019
Sponsor: Martini Hospital Groningen
Congestive Heart Failure
Netherlands
A Prospective Cohort of Obinutuzumab and Chlorambucil (GC) Chemotherapy for the Treatment of Elderly Patients With Chronic Lymphocytic Leukemia Including Next- Generation Sequencing (NGS)-Based AssessmentUnknown
NCT04059081Phase 2Updated Aug 16, 2019
Sponsor: Deok-Hwan Yang
Chronic Lymphocytic Leukemia
South Korea
A Study of Bevacizumab (Avastin) in Neoadjuvant Therapy in Participants With International Federation of Gynecology and Obstetrics (FIGO) Stage IIIC/IV Ovarian, Tubal, or Peritoneal Cancer, Initially UnresectableCompleted
NCT01739218Phase 2Updated Aug 13, 2019
Sponsor: Hoffmann-La Roche
Ovarian Cancer
France
Study of Cobimetinib in Combination With Atezolizumab and Bevacizumab in Participants With Gastrointestinal and Other TumorsCompleted
NCT02876224Phase 1Updated Aug 13, 2019
Sponsor: Hoffmann-La Roche
Colorectal Cancer
United States, Spain
Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of RO7049665 in Healthy VolunteersCompleted
NCT03221179Phase 1Updated Aug 13, 2019
Sponsor: Hoffmann-La Roche
Healthy Volunteers
Netherlands
A Study of Ocrelizumab Compared to Placebo in Patients With Active Rheumatoid Arthritis Who Don't Have a Response to Anti-TNF-α Therapy (SCRIPT)Terminated
NCT00476996Phase 3Updated Aug 12, 2019
Sponsor: Genentech, Inc.
Rheumatoid Arthritis
United States, Argentina, Australia, Belgium, Brazil +20 more
A Study to Evaluate Long Term Safety, Tolerability, and Effectiveness of Olesoxime in Patients With Spinal Muscular Atrophy (SMA)Completed
NCT02628743Phase 2Updated Aug 9, 2019
Sponsor: Hoffmann-La Roche
Muscular Atrophy, Spinal
Belgium, France, Germany, Italy, Netherlands +2 more
A Study of Disease Progression in Participants With Geographic Atrophy Secondary to Age-Related Macular DegenerationTerminated
NCT02399072N/AUpdated Aug 9, 2019
Sponsor: Hoffmann-La Roche
Geographic Atrophy
United States, Argentina, Australia, Brazil, Canada +7 more
OPTIMA: An Observational Study of Mircera (Methoxy Polyethylene Glycol-Epoetin Beta) in Participants With Chronic Kidney Disease Stages 3 and 4 Not on DialysisCompleted
NCT01902628N/AUpdated Aug 9, 2019
Sponsor: Hoffmann-La Roche
Anemia
Greece
A Study of Trastuzumab Emtansine in Participants With Human Epidermal Growth Factor Receptor (HER)2 Immunohistochemistry (IHC)-Positive, Locally Advanced or Metastatic Non-Small Cell Lung Cancer (NSCLC)Completed
NCT02289833Phase 2Updated Aug 7, 2019
Sponsor: Hoffmann-La Roche
Non-Small Cell Lung Cancer
United States, Germany, Italy, Poland, South Korea +2 more
Compare Bioavailability of RO7239361 After Subcutaneous InjectionCompleted
NCT03100630Phase 1Updated Aug 7, 2019
Sponsor: Hoffmann-La Roche
Healthy
United States
A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of GDC-0853 in Healthy Japanese and Caucasian ParticipantsCompleted
NCT03188783Phase 1Updated Aug 7, 2019
Sponsor: Hoffmann-La Roche
Healthy Volunteer
United States
A Study Comparing Maintenance Subcutaneous Rituximab With Observation Only in Participants With Relapsed or Refractory Indolent Non-Hodgkin's Lymphoma Who Had Responded to Rituximab-based Immunochemotherapy Induction and 2-year Maintenance With Subcutaneous RituximabCompleted
NCT01461928Phase 3Updated Aug 6, 2019
Sponsor: Hoffmann-La Roche
Non-Hodgkin's Lymphoma
Albania, Argentina, Austria, Brazil, Bulgaria +19 more
A Study of Atezolizumab Compared With Chemotherapy in Participants With Locally Advanced or Metastatic Urothelial Bladder Cancer [IMvigor211]Completed
NCT02302807Phase 3Updated Aug 1, 2019
Sponsor: Hoffmann-La Roche
Bladder Cancer
United States, Australia, Austria, Belgium, Canada +24 more
Effect of the Interleukin-6 Receptor Antagonist Tocilizumab in Patients With Hand OsteoarthritisCompleted
NCT02477059Phase 3Updated Jul 30, 2019
Sponsor: Assistance Publique - Hôpitaux de Paris
Hand Osteoarthritis
France
A Study of Dalcetrapib in Patients Hospitalized For An Acute Coronary Syndrome (Dal-ACUTE)Completed
NCT01323153Phase 3Updated Jul 30, 2019
Sponsor: Hoffmann-La Roche
Coronary Heart Disease
United States, Czechia, Netherlands, United Kingdom
Decision Making in Multiple Sclerosis Care Under UncertaintyUnknown
NCT04035720NAUpdated Jul 29, 2019
Sponsor: Unity Health Toronto
Multiple Sclerosis
Canada
A Study of Vemurafenib and GDC-0973 (Cobimetinib) in Participants With BRAFV600E Mutation-Positive Metastatic MelanomaCompleted
NCT01271803Phase 1Updated Jul 29, 2019
Sponsor: Hoffmann-La Roche
Malignant Melanoma
United States, Australia
Assessment of the Impact of RNA Genomic Profile on Treatment Decision-making in HER2 Equivocal Breast Cancer PatientsTerminated
NCT03197805NAUpdated Jul 25, 2019
Sponsor: Centre Jean Perrin
Breast Cancer
France

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